Evidence map›Paper›PMID 34802457›Full record

ArticleCell & bioscience2021

Impaired neutralizing antibody response to COVID-19 mRNA vaccines in cancer patients.

Cong Zeng, John P Evans, Sarah Reisinger, Jennifer Woyach, Christina Liscynesky, Zeinab El Boghdadly, Mark P Rubinstein, Karthik Chakravarthy, Linda Saif, Eugene M Oltz and 4 more

Open access · goldAbstract readLetter
In one paragraph

Article in Cell & bioscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 2 pooled it
3.2field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 2 syntheses or guidelines pooled it, 52 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Cong Zeng *Center for Retrovirus Research, The Ohio State University, Columbus, OH, 43210, USA.
John P Evans *Center for Retrovirus Research, The Ohio State University, Columbus, OH, 43210, USA.
Sarah Reisinger *Comprehensive Cancer Center, James Cancer Hospital, The Ohio State University, Columbus, OH, 43210, USA.
Jennifer WoyachDivision of Hematology, James Comprehensive Cancer Center, The Ohio State University, Columbus, OH, 43210, USA.
Christina LiscyneskyInternal Medicine, Division of Infectious Diseases, Department of Internal Medicine, The Ohio State University, Columbus, OH, 43210, USA.
Zeinab El BoghdadlyInternal Medicine, Division of Infectious Diseases, Department of Internal Medicine, The Ohio State University, Columbus, OH, 43210, USA.
Mark P RubinsteinDivision of Medical Oncology, Department of Internal Medicine, Pelotonia Institute for Immuno-Oncology, The Ohio State University Comprehensive Cancer Center, Columbus, OH, 43210, USA.
Karthik ChakravarthyDivision of Medical Oncology, Department of Internal Medicine, Pelotonia Institute for Immuno-Oncology, The Ohio State University Comprehensive Cancer Center, Columbus, OH, 43210, USA.
Linda SaifCenter for Food Animal Health, Animal Sciences Department, OARDC, College of Food, Agricultural and Environmental Sciences,, Wooster, OH, 44691, USA.
Eugene M OltzDepartment of Microbial Infection and Immunity, The Ohio State University, 43210, Columbus, OH, USA.
Richard J GuminaDepartment of Medicine, The Ohio State University, Columbus, OH, 43210, USA.
Peter G ShieldsComprehensive Cancer Center, James Cancer Hospital, The Ohio State University, Columbus, OH, 43210, USA. Peter.Shields@osumc.edu.
Zihai LiDivision of Medical Oncology, Department of Internal Medicine, Pelotonia Institute for Immuno-Oncology, The Ohio State University Comprehensive Cancer Center, Columbus, OH, 43210, USA. Zihai.Li@osumc.edu.
Shan-Lu LiuCenter for Retrovirus Research, The Ohio State University, Columbus, OH, 43210, USA. Liu.6244@osu.edu.ORCID http://orcid.org/0000-0003-1620-3817
The Ohio State University · USThe Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute · US

Funding

Translational Therapeutics Research Program (TT)P30CA016058 · NCI · OHIO STATE UNIVERSITY · PI Jennifer A. Woyach · 1985 to 2026
$132.3M
Project 3: Responding to Changing Serological and Viral Information around COVID-19 (RESPOND)U54CA260582 · NCI · OHIO STATE UNIVERSITY · PI MCALEARNEY, ANN SCHECK, OLTZ, EUGENE M · 2020 to 2024
$10.4M
TIM-mediated Inhibition of HIV Release: Cooperation with SERINC and Antagonism by NefR01AI150473 · NIAID · OHIO STATE UNIVERSITY · PI LIU, SHAN-LU · 2019 to 2021
$995k
NCI NIH HHS P30 CA016058NCI NIH HHS P30CA016058NCI NIH HHS U54 CA260582NCI NIH HHS U54CA260582NIAID NIH HHS R01 AI150473NIH HHS HL127442-01A1NIH HHS NIH RO1 AI150473
6 · The paper itself

Abstract

There is currently a critical need to determine the efficacy of SARS-CoV-2 vaccination for immunocompromised patients. In this study, we determined the neutralizing antibody response in 160 cancer patients diagnosed with chronic lymphocytic leukemia (CLL), lung cancer, breast cancer, and various non-Hodgkin's lymphomas (NHL), after they received two doses of mRNA vaccines. Serum from 46 mRNA vaccinated health care workers (HCWs) served as healthy controls. We discovered that (1) cancer patients exhibited reduced neutralizing antibody titer (NT

Identifiers

PMID34802457
PMCPMC8606166
OpenAlexW3216196257

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.