Observational studyBMC pregnancy and childbirth2021
Low-dose aspirin for primary prevention of adverse pregnancy outcomes in twin pregnancies: an observational cohort study based on propensity score matching.
Observational study in BMC pregnancy and childbirth, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.
- Twin pregnancy and postpartum haemorrhage: a systematic review and meta-analysis.BMC pregnancy and childbirth · 2024Pooled it
- Prospective evaluation of the Simple Fetal Medicine Foundation's first-trimester prediction model for preeclampsia in twin pregnancies.Acta obstetricia et gynecologica Scandinavica · 2026Article
- From empirical regimens to precision prophylaxis: mechanism-based targeting of preeclampsia phenotypes.Frontiers in pharmacology · 2026Review
- Perinatal adverse outcomes in twin pregnancies with preeclampsia complicated by distinct gestational diabetes subtypes.Acta diabetologica · 2025Article
- Low-dose aspirin for the prevention of preeclampsia in women with polycystic ovary syndrome: a retrospective cohort study.BMC pregnancy and childbirth · 2025Article
- Potential impact on using aspirin as the primary prevention of adverse pregnancy outcomes in twins conceived using ART.Scientific reports · 2024Article
- Different pathways for preterm birth between singleton and twin pregnancies: a population-based registry study of 481 176 nulliparous women.BJOG : an international journal of obstetrics and gynaecology · 2023Article
- A nomogram to predict preterm birth in twin pregnancies.American journal of translational research · 2022Article
- Low-dose aspirin in the prevention of preeclampsia in twin pregnancies: A real-world study.Frontiers in cardiovascular medicine · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 4 institutions in 3 countries.
Funding
Abstract
backgroundSince the effectiveness of low-dose aspirin (LDA) in twin pregnancies is uncertain, we aimed to preliminarily assess whether LDA is beneficial in preventing preeclampsia in twin pregnancies.
methodsThis study is an observational study in two hospitals in China. Among 932 women, 277 in the First Affiliated Hospital of Chongqing Medical University were routinely treated with aspirin (100 mg daily) from 12 to 16 weeks to 35 weeks of gestational age, while 655 in Chongqing Health Center for Women and Children were not taking aspirin during pregnancy. We followed each subject and the individual details were recorded.
resultsLDA significantly reduced the risk of preeclampsia (RR 0.48; 95% CI 0.24-0.95) and preterm birth 34 weeks (RR 0.50; 95% CI 0.29-0.86) and showed possible benefits to lower the rate of SGA babies (RR 0.74; 95% CI 0.55-1.00). Moreover, the risk of postpartum hemorrhage was not increased by LDA (RR 0.89; 95% CI 0.35-2.26).
conclusionsTreatment with low-dose aspirin in twin pregnancies could offer some protection against adverse pregnancy outcomes in the absence of significantly increased risk of postpartum hemorrhage.
trial registrationChinese Clinical Trial Registry (ChiCTR); ChiCTR-OOC-16008203 , Retrospectively registered date: April 1st, 2016.
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