Evidence map›Paper›PMID 34802287›Full record

SynthesisCancer control : journal of the Moffitt Cancer Center

Systematic Review and Meta-Analysis of Lysine-Specific Demethylase 1 Expression as a Prognostic Biomarker of Cancer Survival and Disease Progression.

Clement Agboyibor, Jianshu Dong, Clement Y Effah, Emmanuel K Drokow, Waqar Pervaiz, Dié Li, Lei Kang, Xinli Ma, Jian Li, Zhenzhen Liu and 1 more

Open access · goldAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Cancer control : journal of the Moffitt Cancer Center. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Clement AgboyiborSchool of Pharmaceutical Sciences, 12636Zhengzhou University, Zhengzhou, China.ORCID https://orcid.org/0000-0002-2519-9146
Jianshu DongSchool of Pharmaceutical Sciences, 12636Zhengzhou University, Zhengzhou, China.
Clement Y EffahCollege of Public Health, 12636Zhengzhou University, Zhengzhou, China.
Emmanuel K DrokowDepartment of Oncology, 89632Zhengzhou University People's Hospital and Henan Provincial People's Hospital Henan, Zhengzhou, China.ORCID https://orcid.org/0000-0002-7363-9281
Waqar PervaizSchool of Pharmaceutical Sciences, 12636Zhengzhou University, Zhengzhou, China.ORCID https://orcid.org/0000-0002-3283-0944
Dié LiSchool of Pharmaceutical Sciences, 12636Zhengzhou University, Zhengzhou, China.
Lei KangSchool of Pharmaceutical Sciences, 12636Zhengzhou University, Zhengzhou, China.
Xinli MaChina-US(Henan) Hormel Cancer Institute, Zhengzhou, China.
Jian LiChina-US(Henan) Hormel Cancer Institute, Zhengzhou, China.
Zhenzhen Liu12636The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Hong-Min LiuSchool of Pharmaceutical Sciences, 12636Zhengzhou University, Zhengzhou, China.
Zhengzhou University · CNChina-US (Henan) Hormel Cancer Institute · CNFirst Affiliated Hospital of Zhengzhou University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNumerous studies on the prognostic significance of lysine-specific demethylase 1 (LSD1) up-regulation in tumors have different outcomes. The inconsistency originated from various studies looking into the association between LSD1 and tumor cells has prompted the decision of this quantitative systematic review to decipher how up-regulated LSD1 and overall survival (OS) or recurrence-free survival (RFS) or disease-free survival (DFS) are linked in tumor patients.

methodsArticles were searched from online databases such as Embase,

resultsTo shed light on the link between LSD1 up-regulation and the prognosis of diverse tumors, the pooled hazard ratios (HRs) with their 95% confidence intervals (

conclusionDespite the shortfall of the present work, this meta-analysis proposes that LSD1 up-regulation may be a prognostic biomarker for patients with tumors including esophageal tumors and hepatocellular carcinoma. We propose that large-scale studies are vital to substantiate these outcomes.

Indexed as

AdolescentAdultAgedAsian PeopleBiomarkers, TumorCarcinoma, HepatocellularChildDisease-Free SurvivalDisease ProgressionEsophageal NeoplasmsFemaleHistone DemethylasesHumansLiver NeoplasmsMaleMiddle AgedBiomarkers, TumorHistone DemethylasesKDM1A protein, humancancer patientsesophageal tumormeta-analysisoverall survivalup-regulated lysine-specific demethylase 1

Identifiers

PMID34802287
PMCPMC8727833
OpenAlexW3217355801

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.