ArticleJournal of neurogastroenterology and motility2022
Overlap Between Constipation and Gastroesophageal Reflux Disease in Japan: Results From an Internet Survey.
Article in Journal of neurogastroenterology and motility, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.
- Guideline
- Impact of Constipation on Quality of Life, Work Productivity, and Treatment Practices: Findings from the CONNECT Web-Based Survey.Digestion · 2026Article
- Neuropsychiatric Disorders and Constipation: Unraveling Causal Links Through Genetic Analysis.Brain and behavior · 2026Article
- Early Therapeutic Response Predicts Outcome in Chronic Constipation: A Multicenter Prospective Observational Study.Gastroenterology research · 2026Article
- Impact of constipation on patients with schizophrenia and depression: an internet-based survey (CONSIDER survey).Frontiers in psychiatry · 2026Article
- Article
- Effectiveness of an educational program about lifestyle habits on patients' knowledge with gastroesophageal reflux disease.Journal of education and health promotion · 2025Article
- The associations between modifiable risk factors and constipation: a comprehensive mendelian randomization study.BMC gastroenterology · 2024Article
- Overlap Between Gastroesophageal Reflux Disease and Functional Constipation and Associated Risk Factors Among the General Population in Saudi Arabia.International journal of general medicine · 2024Article
- Overlap Between Gastroesophageal Reflux Disease and Irritable Bowel Syndrome and Its Impact on Quality of Life.Cureus · 2023Article
- Relationships between body mass index and constipation, gastroesophageal reflux disease, stool forms based on the Bristol Stool Form Scale, and education level: results from an internet survey in Japan.Journal of clinical biochemistry and nutrition · 2023Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
aimsDetailed evaluations of overlapping constipation and gastroesophageal reflux disease (GERD) have not been conducted in Japan. The REACTION-J2 study examined the overlap of these diseases in Japan.
methodsThis internet-based survey recruited participants from general public survey panels. Questions included demographic and medical data and assessments based on validated measures for constipation and GERD. Associations between background factors affecting constipation/GERD overlap, disease measures, and treatment were also evaluated.
resultsAmong 10 000 survey responses received, functional constipation (Rome IV diagnostic criteria) was reported by 439 participants; chronic constipation (Japanese guidelines) by 3804 participants; and subjective constipation symptoms by 2563 participants. The number of participants with constipation/GERD overlap ranged from 73 to 1533 depending on the criteria used. Regardless of the definition used, all GERD groups had significantly higher odds of being constipated than non-GERD participants: the OR (95% CI) for all 9 combinations of definitions ranged between 1.56 (1.21, 2.01) and 2.67 (2.44, 2.92) (all
conclusionIndividuals with constipation/GERD overlap tend to have worsened symptoms and quality of life.
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