Evidence map›Paper›PMID 34801612›Full record

ArticleToxicology2022

Soluble epoxide hydrolase inhibitor can protect the femoral head against tobacco smoke exposure-induced osteonecrosis in spontaneously hypertensive rats.

Jingyi Xu, Xing Qiu, Gary Yu, Maria Ly, Jun Yang, Rona M Silva, Xun Zhang, Mang Yu, Yinong Wang, Bruce Hammock and 2 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Toxicology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
0.3field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 3 citations in OpenAlex.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 2 countries.

Jingyi XuAffiliated Zhongshan Hospital of Dalian University, Dalian, China.
Xing QiuAffiliated Zhongshan Hospital of Dalian University, Dalian, China.
Gary YuMedical Scientist Training Program, University of Pittsburgh, Pittsburgh, PA, USA.
Maria LyMedical Scientist Training Program, University of Pittsburgh, Pittsburgh, PA, USA.
Jun YangDepartment of Entomology and Nematology, University of California, Davis, CA, USA.
Rona M SilvaCenter for Health and the Environment, University of California, Davis, CA, USA.
Xun ZhangNeuroendocrine Research Laboratory, Harvard University, Cambridge, MA, USA.
Mang YuDepartment of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA.
Yinong WangSchool of Materials Science and Engineering, Dalian University of Technology, Dalian, China.
Bruce HammockDepartment of Entomology and Nematology, University of California, Davis, CA, USA.
Kent E PinkertonCenter for Health and the Environment, University of California, Davis, CA, USA.
Dewei ZhaoAffiliated Zhongshan Hospital of Dalian University, Dalian, China. Electronic address: zhaodewei2016@163.com.
University of California, Davis · USAffiliated Zhongshan Hospital of Dalian University · CNUniversity of Pittsburgh Medical Center · USDalian University of Technology · CNHarvard University · USStanford University · US

Funding

Workshop on Environmental Technology Transfer and EntrepreneurshipP42ES004699 · NIEHS · UNIVERSITY OF CALIFORNIA DAVIS · PI HAMMOCK, BRUCE D · 1987 to 2021
$50.1M
HYDROLYTIC ENZYMES IN THE METABOLISM OF TOXINSR01ES002710 · NIEHS · UNIVERSITY OF CALIFORNIA DAVIS · PI HAMMOCK, BRUCE D · 1985 to 2018
$4.0M
NIEHS NIH HHS P42 ES004699NIEHS NIH HHS R01 ES002710
6 · The paper itself

Abstract

Exposure to tobacco smoke (TS) has been considered a risk factor for osteonecrosis of the femoral head (ONFH). Soluble epoxide hydrolase inhibitors (sEHIs) have been found to reduce inflammation and oxidative stress in a variety of pathologies. This study was designed to assess the effect of sEHI on the development of ONFH phenotypes induced by TS exposure in spontaneously hypertensive (SH) rats. SH and normotensive Wistar Kyoto (WKY) rats were exposed to filtered air (FA) or TS (80 mg/m3 particulate concentration) 6 h/day, 3 days/week for 8 weeks. During this period, sEHI was delivered through drinking water at a concentration of 6 mg/L. Histology, immunohistochemistry, and micro-CT morphometry were performed for phenotypic evaluation. As results, TS exposure induced significant increases in adipocyte area, bone specific surface (BS/BV), and trabecular separation (Tb.SP), as well as significant decreases in bone mineral density (BMD), percent trabecular area (Tb.Ar), HIF-1a expression, bone volume fraction (BV/TV), trabecular numbers (Tb.N), and trabecular thickness (Tb.Th) in both SH and WKY rats. However, the protective effects of sEHI were mainly observed in TS-exposed SH rats, specifically in the density of osteocytes, BMD, Tb.Ar, HIF-1a expression, BV/TV, BS/BV, Tb.N, and Tb.SP. Our study confirms that TS exposure can induce ONFH especially in SH rats, and suggests that sEHI therapy may protect against TS exposure-induced osteonecrotic changes in the femoral head.

Indexed as

SmokeAnimalsDisease Models, AnimalEnzyme InhibitorsEpoxide HydrolasesFemur HeadFemur Head NecrosisHypertensionHypoxia-Inducible Factor 1, alpha SubunitMaleOsteocytesPhenylurea CompoundsPiperidinesRatsRats, Inbred SHRRats, Inbred WKY1-trifluoromethoxyphenyl-3-(1-propionylpiperidine-4-yl)ureaEnzyme InhibitorsEPHX2 protein, ratEpoxide HydrolasesHif1a protein, ratHypoxia-Inducible Factor 1, alpha SubunitPhenylurea CompoundsPiperidinesSmokeVascular Endothelial Growth Factor Avascular endothelial growth factor A, ratOsteonecrosis the femoral headSoluble epoxide hydrolase inhibitorsSpontaneously hypertensive ratsTobacco smoke

Identifiers

PMID34801612
PMCPMC9484547
OpenAlexW3217299031

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.