ArticleJACC. Cardiovascular imaging2022
Prognostic Implications of Progressive Systemic Ventricular Dysfunction in Congenitally Corrected Transposition of Great Arteries.
Article in JACC. Cardiovascular imaging, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 39 citations in OpenAlex.
- Clinical Applications of Right Ventricular Strain by Two-Dimensional Speckle-Tracking Echocardiography.Echocardiography (Mount Kisco, N.Y.) · 2026Review
- Applications of speckle tracking echocardiography in paediatric and congenital heart disease: an expert consensus paper from AEPC Imaging Working Group.European heart journal. Imaging methods and practice · 2026Article
- Correlates and Prognostic Value of Serial N-Terminal Pro-B-Type Natriuretic Peptide Assay in Congenitally Corrected Transposition of the Great Arteries.Journal of the American Heart Association · 2026Article
- Heart Failure Therapy Improves Outcomes in Adults With Congenital Heart Disease and Left Ventricular Dysfunction.JACC. Advances · 2026Article
- Clinical implications of progressive systemic ventricular dysfunction in adults with Fontan palliation.International journal of cardiology. Congenital heart disease · 2025Article
- Cardiovascular imaging in children with cardiac implantable electronic devices.Pediatric radiology · 2025Review
- Clinical outcomes after implantation of bioprosthetic valves in adults with congenital heart disease.International journal of cardiology. Congenital heart disease · 2025Article
- Role of strain imaging for risk stratification in Fontan patients with normal ventricular ejection fraction.European heart journal. Cardiovascular Imaging · 2025Article
- Echocardiographic Assessment of Atrial Function in Patients With Fontan Palliation: Feasibility, Reproducibility, and Prognostic Implications.CJC pediatric and congenital heart disease · 2025Article
- Progressive LV Dysfunction and Adverse Outcomes After Aortic Valve Replacement With Bioprosthetic Valves in Young Patients.Circulation. Cardiovascular imaging · 2025Article
- Relationship Between Atrial Dysfunction and Atrial Arrhythmias in Adults With Fontan Palliation: Role of Atrial Strain Imaging.Journal of the American Heart Association · 2025Article
- Hemodynamics in Adults with Systemic Right Ventricles: Differences Between Congenitally Corrected and Complete Transposition of the Great Arteries.Pediatric cardiology · 2025Article
- Sex Differences in Outcomes of Adults with Repaired Coarctation of Aorta and Concomitant Aortic Valve Disease.CJC open · 2024Article
- Tricuspid Regurgitation Stratification Predicts the Time Course of Systemic Right Ventricle Dysfunction Among Patients on ACE-I/ARB.CJC pediatric and congenital heart disease · 2024Article
- A leadless pacemaker implantation for a patient with systemic right ventricle under ventricular assist device support.Journal of cardiology cases · 2024Article
- Biventricular performance in adults with a systemic right ventricle: new insights from myocardial work analysis.The international journal of cardiovascular imaging · 2024Article
- Longitudinal changes in systemic right ventricular remodeling in adult patients with transposition of the great vessels as assessed by cardiovascular magnetic resonance imaging.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2024Article
- End-stage heart failure in congenitally corrected transposition of the great arteries: a multicentre study.European heart journal · 2023Article
- Prognostic Value of the Anatomic-Physiologic Classification in Adults With Congenital Heart Disease.Circulation. Heart failure · 2023Article
- Overview of Long-Term Outcome in Adults with Systemic Right Ventricle and Transposition of the Great Arteries: A Review.Diagnostics (Basel, Switzerland) · 2023Review
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4 authors at 1 institution in 1 country.
Funding
Abstract
objectivesThe purpose of this study was to determine the risk factors for and prognostic implications of progressive right ventricular systolic dysfunction (RVD) in adults with congenitally corrected transposition of great arteries.
backgroundThere are no effective therapies for RVD; hence the need to identify and modify risk factors for progressive RVD.
methodsRV systolic function was assessed by using RV longitudinal strain (RV-LS). The first echocardiogram (baseline echocardiogram) and all subsequent annual echocardiograms performed within 5 years from the baseline echocardiogram were analyzed. Progressive RVD (temporal decline in RV-LS) was assessed as the average annual change in RV-LS within 5 years of imaging follow-up.
resultsOf 186 patients (mean age 40 ± 12 years), the RV-LS at baseline was -17% ± 4%, and the annual decline in RV-LS was -4% (95% CI: -6 to -2). The risk factors for progressive RVD were left ventricular (LV) systolic dysfunction, LV pacing, and systemic hypertension. Cardiovascular events (heart failure hospitalization, heart transplant, and death) occurred in 57 (27%) patients. Progressive RVD was associated with cardiovascular events, independent of RV systolic function at baseline. In subgroup analyses assessing impact of therapies (medical therapy, cardiac resynchronization therapy, and tricuspid valve replacement), only tricuspid valve replacement was associated with improvement in RV systolic function when performed before onset of RVD.
conclusionsPatients with congenitally corrected transposition of great arteries were at risk for progressive RVD, and the risk factors for progressive RVD were LV pacing, systemic hypertension, and concomitant LV dysfunction. Further studies are required to determine whether strict blood pressure control and early tricuspid valve replacement will prevent progressive RVD.
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