Evidence map›Paper›PMID 34801350›Full record

ArticleThe Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation2022

Non-patient factors associated with infections in LVAD recipients: A scoping review.

Supriya Shore, Michael J Pienta, Tessa M F Watt, Gardner Yost, Whitney A Townsend, Lourdes Cabrera, Michael D Fetters, Carol Chenoweth, Keith D Aaronson, Francis D Pagani and 2 more

Abstract readScoping Review
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Guideline
  2. Increased neutrophil extracellular trap formation in left ventricular assist device driveline infections: an initial report.Postepy w kardiologii interwencyjnej = Advances in interventional cardiology · 2025
    Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Supriya ShoreDivision of Cardiovascular Medicine. Electronic address: shores@med.umich.edu.
Michael J PientaDepartment of Cardiac Surgery.
Tessa M F WattDepartment of Cardiac Surgery.
Gardner YostDepartment of Cardiac Surgery.
Whitney A TownsendTaubman Health Sciences Library, University of Michigan, Ann Arbor, Michigan.
Lourdes CabreraDepartment of Cardiac Surgery.
Michael D FettersMixed Methods Program and Department of Family Medicine.
Carol ChenowethDivision of Infectious Diseases.
Keith D AaronsonDivision of Cardiovascular Medicine.
Francis D PaganiDepartment of Cardiac Surgery.
Donald S LikoskyDepartment of Cardiac Surgery.
Michigan Congestive Heart Failure Investigators

Funding

Understanding and Addressing Variation in Healthcare-Associated Infections After Durable Ventricular Assist Device TherapyR01HS026003 · AHRQ · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LIKOSKY, DONALD S · 2018 to 2022
$2.3M
AHRQ HHS R01 HS026003
6 · The paper itself

Abstract

backgroundInfections are the most common complication in recipients of durable left ventricular assist devices (LVAD) and are associated with increased morbidity, mortality, and expenditures. The existing literature examining factors associated with infection in LVAD recipients is limited and principally comprises single-center studies. This scoping review synthesizes all available evidence related to identifying modifiable, non-patient factors associated with infections among LVAD recipients.

methodsPublished studies were identified through searching 5 bibliographic databases: PubMed, Scopus, EMBASE, CINAHL, and Web of Science Core Collection. Inclusion criteria required examination of factors associated with infections among recipients of contemporary, implantable, continuous flow LVADs. Key study characteristics were extracted by 4 independent reviewers and current literature described narratively. The Systems Engineering Initiative for Patient Safety (SEIPS) model was used to develop a taxonomy for non-patient related factors (e.g., tasks, tools, technologies, organization, and environment) associated with infections following LVAD implantation. All analyses took place between February 2019 and May 2021.

findingsA total of 43 studies met inclusion criteria. The majority of included studies were observational (n = 37), single-center (n = 29), from the U.S. (n = 38), and focused on driveline infections (n = 40). Among the 22 evaluated sub-domains of non-patient related factors, only two: increasing center experience and establishing a silicone-skin interface at the driveline exit site, were identified as consistently being associated with a lower risk of infection.

conclusionThis review identified 43 studies that described non-patient related factors associated with infection in LVAD recipients. Only two factors were consistently associated with lower infection risk in LVAD recipients: increasing experience and establishing a silicone-skin interface at driveline exit site. The large variability in reporting across multiple studied interventions limited the ability to discern their effectiveness.

Indexed as

Heart-Assist DevicesHumansProsthesis-Related Infectionsdriveline infectioninfectioninfection preventionLVADsurgical techniques, antibiotic prophylaxis

Identifiers

PMID34801350
PMCPMC9094089

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.