Evidence map›Paper›PMID 34801282›Full record

ArticleJournal of substance abuse treatment2022

Multi-level implementation factors that influence scale-up of methadone maintenance treatment in Moldovan prisons: A qualitative study.

George L O'Hara, Amanda R Liberman, Maxim Polonsky, Lyuba Azbel, Ruthanne Marcus, Svetlana Doltu, Sergiu Cugut, Frederick L Altice

Open access · greenAbstract read
In one paragraph

Article in Journal of substance abuse treatment, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 3 countries.

George L O'HaraYale University School of Medicine, Section of Infectious Diseases, 333 Cedar St, New Haven, CT 06510, USA.
Amanda R LibermanYale University School of Medicine, Section of Infectious Diseases, 333 Cedar St, New Haven, CT 06510, USA. Electronic address: amanda.liberman@yale.edu.
Maxim PolonskyYale University School of Medicine, Section of Infectious Diseases, 333 Cedar St, New Haven, CT 06510, USA.
Lyuba AzbelLondon School of Hygiene and Tropical Medicine, Keppel St, Bloomsbury, London WC1E 7HT, UK.
Ruthanne MarcusYale University School of Medicine, Section of Infectious Diseases, 333 Cedar St, New Haven, CT 06510, USA. Electronic address: ruthanne.marcus@yale.edu.
Svetlana DoltuAct for Involvement (AFI) Nongovernmental organization, Varșovia St 2060, Chișinău 2060, Republic of Moldova.
Sergiu CugutAct for Involvement (AFI) Nongovernmental organization, Varșovia St 2060, Chișinău 2060, Republic of Moldova. Electronic address: scugut@afi.md.
Frederick L AlticeYale University School of Medicine, Section of Infectious Diseases, 333 Cedar St, New Haven, CT 06510, USA; Yale University School of Public Health, Division of Epidemiology of Microbial Diseases, 60 College St, New Haven, CT 06510, USA. Electronic address: frederick.altice@yale.edu.
Yale University · USLondon School of Hygiene & Tropical Medicine · GBUniversitatea de Stat din Tiraspol · MD

Funding

Research Mentoring and Building Capacity of underrepresented Minority Research Scientists in India.D43TW010540 · FIC · YALE UNIVERSITY · PI MICHELE BARRY, Eva Harris · 2017 to 2026
$15.5M
Prison Interventions and HIV Prevention CollaborationR01DA029910 · NIDA · YALE UNIVERSITY · PI FREDERICK LEWIS ALTICE · 2010 to 2026
$7.9M
Expanding Medication Assisted Therapy in Ukraine (ExMAT)R01DA033679 · NIDA · YALE UNIVERSITY · PI ALTICE, FREDERICK LEWIS · 2012 to 2021
$6.4M
Global Health Fellows and Scholars Research TrainingR25TW009338 · FIC · UNIVERSITY OF CALIFORNIA BERKELEY · PI BARRY, MICHELE, KO, ALBERT ICKSANG · 2012 to 2016
$5.2M
Enhancing Health Outcomes Among HIV+ Substance AbusersK24DA017072 · NIDA · YALE UNIVERSITY · PI ALTICE, FREDERICK LEWIS · 2003 to 2012
$1.5M
FIC NIH HHS D43 TW010540FIC NIH HHS R25 TW009338NIDA NIH HHS K24 DA017072NIDA NIH HHS R01 DA029910NIDA NIH HHS R01 DA033679
6 · The paper itself

Abstract

introductionPeople who inject drugs (PWID) are overrepresented in prison populations, especially in the Eastern European and Central Asian region (EECA), where HIV incidence and mortality continue to rise. Modeling data suggest that methadone maintenance treatment (MMT) scale-up in prison with continuation after release could substantially reduce new HIV infections. Moldova, one of four countries in the EECA to have introduced MMT in prisons, has faced challenges with its scale-up.

methodTo improve implementation of MMT in Moldovan prisoners, we analyzed the qualitative interviews of 44 recently released Moldovan prisoners with opioid use disorder who either accepted or rejected MMT while incarcerated; these 44 were among a subset of 56 participants in a quantitative survey who had complete interview data. After translating and back-translating interviews, we used content analysis to identify key barriers and facilitators to MMT uptake.

resultsOur qualitative analyses revealed that positive attitudes toward methadone facilitated treatment uptake, yet the study identified three thematic barriers as to why PWID do not accept MMT while in prison, including: 1) negative personal attitudes toward MMT; 2) stigmatization of MMT by informal hierarchies within prison; and 3) distrust of the formal prison hierarchy (i.e., administration), which provides MMT.

conclusionOverall, the social forces of the two prisoner hierarchies and distrust between them appeared to outweigh the perceived benefits of MMT and impacted MMT uptake. Here we provide strategies to promote MMT more effectively in prison settings.

Indexed as

HIV InfectionsPrisonersSubstance Abuse, IntravenousHumansMethadoneOpiate Substitution TreatmentPrisonsMethadoneEvidence-based interventionHIVImplementation scienceMethadoneMoldovaPrisons

Identifiers

PMID34801282
PMCPMC10879837
OpenAlexW3213917916

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.