Evidence map›Paper›PMID 34800988›Full record

ArticleBMC cancer2021

A comprehensive approach to risk factors for upper arm morbidities following breast cancer treatment: a prospective study.

Ifat Klein, Leonid Kalichman, Noy Chen, Sergio Susmallian

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC cancer, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03389204 (Upper Limb Function After Breast Cancer Surgery), which is not on this map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
2.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03389204 nacompletednot on this map

Upper Limb Function After Breast Cancer Surgery: the Role of Post-operative Physical Therapy Intervention- Randomized Control Trial

TypeinterventionalSponsorAssuta Medical CenterRan2018 to 2019Enrolled160ConditionsBreast NeoplasmsArmsPHYSICAL THERAPY
3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.

  1. Pooled it
  2. Factors affecting shoulder joint range of motion after breast cancer surgery: a retrospective cohort study in Japan.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Article
  3. Review
  4. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Ifat KleinDepartment of Physical Therapy, Assuta Medical Center, Tel Aviv, Israel.
Leonid KalichmanDepartment of physical therapy, Faculty of Health Sciences, Recanati School for Community Health Professions, Ben-Gurion University of the Negev, Beer Sheva, Israel.ORCID https://orcid.org/0000-0003-2987-4396
Noy ChenDepartment of Physical Therapy, Assuta Medical Center, Tel Aviv, Israel.
Sergio SusmallianDepartment of Surgery, Assuta Medical Center, 20 Habarzel Street, 69710, Tel Aviv, Israel. sergio9@bezeqint.net.ORCID http://orcid.org/0000-0003-3069-8334
Ben-Gurion University of the Negev · ILAssuta Medical Center · IL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundBreast cancer surgery frequently causes deficiencies in shoulder functioning. The study pourpode is to identify risk factors for prolonged pain, reduction in function, and decrease in range of motion (ROM) in BC patients.

methodsA prospective cohort study was designed in a private hospital; between October 2018 and April 2019 with a follow-up of 6 months. Patients following BC surgery, were divided by arm morbidities, and the different risk facrors were evaluated using univariate analysis and logistic regression.

resultsA total of 157 patients were included in the study. Risk factors for functional disabilities included; pain levels during hospitalization NPRS 1.2 (±0.8) compared to patients with no disabilities 0.5 ± 0.7 (p = .006), the size of tumors more than 1.4 ± 0.8 cm. compared with no morbidities 0.8 ± 0.9 cm. (p = .046), and breast reconstructions (p = .030). Risk factors for prolonged pain includes mastectomy (p = .006), breast reconstruction (p = .011), more than three dissected lymph nodes (p = .002), the presence of preoperative pain (p < .001), in-hospital pain (p < .001), axillary web syndrome (p < .001) and lymphedema (p < .001). Risk factors for decreased ROM were more than three dissected lymph nodes (p = .027), radiation (p = .018), and the size of dissected tissue (p = .035). Postoperative physical therapy appears to reduce the incidence of prolonged pain (p = .013) and regular physical activity may reduce long term functional disabilities (p = .021).

conclusionsUpper arm morbidity following BC treatments affect up to 70% of the patients. Identifying the different risk and beneficial factors may improve awareness among physicians to refer patients to early rehabilitation programs and thus avoid chronic morbidity and improve the course of recovery.

trial registrationThe study was registered in Clinical trial with the ID number: NCT03389204 .

Indexed as

ArmAnalysis of VarianceBreast NeoplasmsFemaleHumansLymphedemaLymph Node ExcisionMammaplastyMastectomyMiddle AgedPhysical Therapy ModalitiesPostoperative CarePostoperative ComplicationsPostoperative PainProspective StudiesRange of Motion, ArticularFunctional limitationsPainPhysical activityPhysical therapy

Identifiers

PMID34800988
PMCPMC8605604
OpenAlexW3215215712

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.