Evidence map›Paper›PMID 34800762›Full record

ArticleCellular immunology2021

Caspase-11 regulates lung inflammation in response to house dust mites.

Arwa Abu Khweek, Marisa R Joldrichsen, Eunsoo Kim, Zayed Attia, Kathrin Krause, Kylene Daily, Shady Estfanous, Kaitlin Hamilton, Asmaa Badr, Midhun N K Anne and 7 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cellular immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. A Role for Non-Canonical Caspases in Fungal Allergic Airway Disease.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2026
    Article
  2. Review
  3. Article
  4. Review
  5. Review
  6. Long-term exposure to house dust mites accelerates lung cancer development in mice.Journal of experimental & clinical cancer research : CR · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 2 institutions in 2 countries.

Arwa Abu KhweekDepartment of Microbial Infection and Immunity, The Ohio State University, Columbus OH 43210, USA; Department of Biology and Biochemistry, Birzeit University, West Bank, Palestine.
Marisa R JoldrichsenDepartment of Veterinary Biosciences, The Ohio State University, Columbus OH 43210, USA.
Eunsoo KimDepartment of Veterinary Biosciences, The Ohio State University, Columbus OH 43210, USA.
Zayed AttiaDepartment of Veterinary Biosciences, The Ohio State University, Columbus OH 43210, USA.
Kathrin KrauseDepartment of Microbial Infection and Immunity, The Ohio State University, Columbus OH 43210, USA.
Kylene DailyDepartment of Microbial Infection and Immunity, The Ohio State University, Columbus OH 43210, USA.
Shady EstfanousDepartment of Microbial Infection and Immunity, The Ohio State University, Columbus OH 43210, USA.
Kaitlin HamiltonDepartment of Microbial Infection and Immunity, The Ohio State University, Columbus OH 43210, USA.
Asmaa BadrDepartment of Microbial Infection and Immunity, The Ohio State University, Columbus OH 43210, USA.
Midhun N K AnneDepartment of Microbial Infection and Immunity, The Ohio State University, Columbus OH 43210, USA.
Mostafa EltobgyDepartment of Microbial Infection and Immunity, The Ohio State University, Columbus OH 43210, USA.
Kara N CorpsDepartment of Veterinary Biosciences, The Ohio State University, Columbus OH 43210, USA.
Cierra CaraficeDepartment of Microbial Infection and Immunity, The Ohio State University, Columbus OH 43210, USA.
Xiaoli ZhangCenter for Biostatistics, The Ohio State University, Columbus OH 43210, USA.
Mikhail A GavrilinDepartment of Internal Medicine, The Ohio State University, Columbus OH 43210, USA.
Prosper N BoyakaDepartment of Microbial Infection and Immunity, The Ohio State University, Columbus OH 43210, USA; Department of Veterinary Biosciences, The Ohio State University, Columbus OH 43210, USA; Infectious Diseases Institute, The Ohio State University, Columbus OH 43210, USA. Electronic address: boyaka.1@osu.edu.
Amal O AmerDepartment of Microbial Infection and Immunity, The Ohio State University, Columbus OH 43210, USA. Electronic address: amal.amer@osumc.edu.
The Ohio State University · USBirzeit University · PS

Funding

Translational Therapeutics Research Program (TT)P30CA016058 · NCI · OHIO STATE UNIVERSITY · PI Jennifer A. Woyach · 1985 to 2026
$132.3M
MOLECULAR ADJUVANTS FOR NALT-BASED IMMUNITY TO ANTHRAXR01AI043197 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BOYAKA, PROSPER N · 1998 to 2013
$4.6M
Unraveling the role of the CFTR ion channel in susceptibility to SARS-CoV-2 infection and inflammationR01AI124121 · NIAID · OHIO STATE UNIVERSITY · PI AMER, AMAL O, CORMET-BOYAKA, ESTELLE A · 2016 to 2020
$3.7M
Targeting myeloid cells for regulation of alum-based immunityR01AI145144 · NIAID · OHIO STATE UNIVERSITY · PI BOYAKA, PROSPER N · 2020 to 2024
$3.1M
VZ VIRUS: CLINICAL IMPLICATIONS OF IMMUNITYR01AI024021 · NIAID · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI SILVERSTEIN, SAUL J · 1986 to 2008
$3.0M
Regulation of mucosal IgA and allergic inflammation by intestinal epithelial cellsR01DK101323 · NIDDK · OHIO STATE UNIVERSITY · PI BOYAKA, PROSPER N · 2015 to 2019
$1.7M
The role of microRNA-calibrated autophagy in innate immunity and inflammationR01HL127651 · NHLBI · OHIO STATE UNIVERSITY · PI AMER, AMAL O, CORMET-BOYAKA, ESTELLE A · 2015 to 2018
$1.5M
NCI NIH HHS P30 CA016058NHLBI NIH HHS R01 HL127651NIAID NIH HHS R01 AI024021NIAID NIH HHS R01 AI043197NIAID NIH HHS R01 AI124121NIAID NIH HHS R01 AI145144NIDDK NIH HHS R01 DK101323
6 · The paper itself

Abstract

Asthma is an inflammatory lung disorder characterized by mucus hypersecretion, cellular infiltration, and bronchial hyper-responsiveness. House dust mites (HDM) are the most prevalent cause of allergic sensitization. Canonical and noncanonical inflammasomes are multiprotein complexes that assemble in response to pathogen or danger-associated molecular patterns (PAMPs or DAMPs). Murine caspase-11 engages the noncanonical inflammasome. We addressed the role of caspase-11 in mediating host responses to HDM and subsequent allergic inflammation using caspase-11

Indexed as

AnimalsCaspases, InitiatorHypersensitivityMiceMice, Inbred C57BLMice, KnockoutPneumoniaPyroglyphidaeCasp4 protein, mouseCaspases, Initiator

Identifiers

PMID34800762
PMCPMC8714054
OpenAlexW3181873765

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.