ArticleInfectious diseases now2022
Prevalence and factors associated with symptom persistence: A prospective study of 429 mild COVID-19 outpatients.
Article in Infectious diseases now, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 2 of them syntheses that pooled it.
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Who cites it
7 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Pooled it
- Pooled it
- COVID-19 symptom severity and duration among outpatients, July 2021-May 2023: The PROTECT observational study.PloS one · 2025Observational
- The Multisystem Impact of Long COVID: A Comprehensive Review.Diagnostics (Basel, Switzerland) · 2024Review
- Influenza and COVID-19 co-infection and vaccine effectiveness against severe cases: a mathematical modeling study.Frontiers in cellular and infection microbiology · 2024Article
- Post COVID-19 Condition in Children and Adolescents: An Emerging Problem.Frontiers in pediatrics · 2022Review
- Gastrointestinal manifestations of long COVID: A systematic review and meta-analysis.Therapeutic advances in gastroenterology · 2022Article
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Authors and funding
23 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionPersistent symptoms have recently emerged as a clinical issue in COVID-19. We aimed to assess the prevalence and risk factors in symptomatic non-hospitalized individuals with mild COVID-19.
methodsWe performed a prospective cohort study of symptomatic COVID-19 outpatients, from March to May 2020, with weekly phone calls from clinical onset until day 30 and up to day 60 in case of persistent symptoms. The main outcomes were the proportion of patients with complete recovery at day 30 and day 60 and factors associated with persistent symptoms.
resultsWe enrolled 429 individuals mostly women (72.5%) and healthcare workers (72.5%), with a median age of 41.6 years [IQR 30-51.5]. Symptoms included: cough (69.7%), asthenia (68.8%), anosmia (64.8%), headaches (64.6%), myalgia (62.7%), gastrointestinal symptoms (61.8%), fever (61.5%), and ageusia (60.8%). Mean duration of disease was 27 days (95%CI: 25-29). The rate of persistent symptoms was 46.8% at day 30 and 6.5% at day 60 consisting in asthenia (32.6%), anosmia (32.6%), and ageusia (30.4%). The probability of complete recovery was 56.3% (95%CI: 51.7-61.1) at day 30 and 85.6% (95%CI: 81.2-89.4) at day 60. Factors associated with persistent symptoms were age>40 (HR 0.61), female sex (HR 0.70), low cycle threshold (HR 0.78), and ageusia (HR 0.59).
conclusionsCOVID-19 - even in its mild presentation - led to persistent symptoms (up to one month) in nearly half of individuals. Identification of risk factors such as age, gender, ageusia and viral load is crucial for clinical management and argues for the development of antiviral agents.
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