ArticleNeuroImage2022
An MRI method for parcellating the human striatum into matrix and striosome compartments in vivo.
Article in NeuroImage, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.
- Common and disorder-specific aberrant activation during reward and loss processing in major depressive disorder and addiction: a meta-analysis of fMRI studies.Molecular psychiatry · 2026Pooled it
- Noninvasive Mapping of Striosome-Matrix Imbalance in Early Psychosis.Biological psychiatry global open science · 2026Article
- A diffusion MRI-based structural assessment of the striatal compartments, striosome and matrix, in Obsessive Compulsive Disorder.Research square · 2026Article
- Prefrontal modulation of striatal engagement: a hierarchical framework for goal-directed behavior.Communications biology · 2026Review
- In Humans, fMRI Reveals That Striosome-Like and Matrix-Like Striatal Voxels Are Engaged in Different Phases of Movement.Human brain mapping · 2026Article
- Structural brain analysis in focal upper limb dystonia.Scientific reports · 2026Article
- Hippocampal Projections to the Striatal Compartments, Striosome and Matrix, are Spatially Segregated in CA1.bioRxiv : the preprint server for biology · 2026Article
- Striosome-Like Structural Connectivity Is Reduced in the Rostral Putamen in Anxiety Disorder.Depression and anxiety · 2026Article
- The striatal matrix compartment is expanded in autism spectrum disorder.Journal of neurodevelopmental disorders · 2025Article
- Depression-associated reductions in putaminal volume are accompanied by a shift from matrix-like to striosome-like structural connectivity.Frontiers in psychiatry · 2025Article
- The striatal compartments, striosome and matrix, are embedded in largely distinct resting-state functional networks.Frontiers in neural circuits · 2025Article
- Analysis of striatal connectivity corresponding to striosomes and matrix in de novo Parkinson's disease and isolated REM behavior disorder.NPJ Parkinson's disease · 2024Article
- In humans, insulo-striate structural connectivity is largely biased toward either striosome-like or matrix-like striatal compartments.bioRxiv : the preprint server for biology · 2024Article
- An MRI Compatible Data Acquisition Device for Rat Brain Recording Inside 16.4T Magnet.IEEE transactions on biomedical circuits and systems · 2024Article
- In Humans, Insulo-striate Structural Connectivity is Largely Biased Toward Either Striosome-like or Matrix-like Striatal Compartments.Neuroscience insights · 2024Article
- DARPP-32 cells and neuropil define striosomal system and isolated matrix cells in human striatum.The Journal of comparative neurology · 2023Article
- In humans, striato-pallido-thalamic projections are largely segregated by their origin in either the striosome-like or matrix-like compartments.Frontiers in neuroscience · 2023Article
- Dystonia: Still a Mysterious Syndrome.Life (Basel, Switzerland) · 2022Article
Corrections and comments
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Authors and funding
10 authors at 8 institutions in 3 countries.
Funding
Abstract
The mammalian striatum is comprised of intermingled tissue compartments, matrix and striosome. Though indistinguishable by routine histological techniques, matrix and striosome have distinct embryologic origins, afferent/efferent connections, surface protein expression, intra-striatal location, susceptibilities to injury, and functional roles in a range of animal behaviors. Distinguishing the compartments previously required post-mortem tissue and/or genetic manipulation; we aimed to identify matrix/striosome non-invasively in living humans. We used diffusion MRI (probabilistic tractography) to identify human striatal voxels with connectivity biased towards matrix-favoring or striosome-favoring regions (determined by prior animal tract-tracing studies). Segmented striatal compartments replicated the topological segregation and somatotopic organization identified in animal matrix/striosome studies. Of brain regions mapped in prior studies, our human brain data confirmed 93% of the compartment-selective structural connectivity demonstrated in animals. Test-retest assessment on repeat scans found a voxel classification error rate of 0.14%. Fractional anisotropy was significantly higher in matrix-like voxels, while mean diffusivity did not differ between the compartments. As mapped by the Talairach human brain atlas, 460 regions were significantly biased towards either matrix or striosome. Our method allows the study of striatal compartments in human health and disease, in vivo, for the first time.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.