Evidence map›Paper›PMID 34800198›Full record

ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2022

Increased high-mobility group box 1 levels are associated with depression after acute ischemic stroke.

Wanying Shan, Liang Xu, Zhuoyin Qiu, Jingwen Wang, Jiaxing Shao, Jie Feng, Jie Zhao

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Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Wanying Shan *Department of Neurology, Suzhou Ninth People's Hospital, Soochow University, No. 2666 Ludang Road, Suzhou, 215200, Jiangsu, China.
Liang Xu *Department of Anesthesiology, the First Affiliated Hospital of Soochow University, No.899 Pinghai Road, Suzhou, 215000, Jiangsu, China.
Zhuoyin QiuDepartment of Neurology, Suzhou Ninth People's Hospital, Soochow University, No. 2666 Ludang Road, Suzhou, 215200, Jiangsu, China.
Jingwen WangDepartment of Neurology, Suzhou Ninth People's Hospital, Soochow University, No. 2666 Ludang Road, Suzhou, 215200, Jiangsu, China.
Jiaxing ShaoDepartment of Neurology, Suzhou Ninth People's Hospital, Soochow University, No. 2666 Ludang Road, Suzhou, 215200, Jiangsu, China.
Jie FengDepartment of Neurology, Suzhou Ninth People's Hospital, Soochow University, No. 2666 Ludang Road, Suzhou, 215200, Jiangsu, China. 1016909765@qq.com.
Jie ZhaoDepartment of Gerontology, Suzhou Ninth People's Hospital, Soochow University, No. 2666 Ludang Road, Suzhou, 215200, Jiangsu, China. DrZHao_0529@163.com.ORCID http://orcid.org/0000-0002-2214-2785

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background and purposeIncreased high-mobility group box 1 (HMGB1) levels were found in patients after acute ischemic stroke. The aim of this study was to examine whether the circulating HMGB1 levels could predict the 3-month post-stroke depression (PSD).

methodsThe subjects were first-ever ischemic stroke patients who were hospitalized during the period from July 2020 to December 2020. HMGB1 concentrations were measured by enzyme-linked immunosorbent assay after admission. A 24-item Hamilton Depression Rating Scale was performed to evaluate PSD at 3 months after stroke.

resultsThe analyses included 324 participants (mean age, 63.7 years; 171 male). Ninety-four patients (29.0%) were diagnosed as having PSD at 3 months. The median serum HMGB1 levels at admission was 7.5 ng/mL (IQR, 4.4-11.3 ng/mL). The PSD distribution across the HMGB1 quartiles ranged between 17.5% (first quartile) and 57.5% (fourth quartile). After covariate adjustments, the fourth quartile of HMGB1 was found to be associated with a higher risk of PSD (as compared with first HMGB1 quartile, odd ratio, 1.26; 95% confidence interval [CI], 1.17-1.35; P < 0.001). The area under the receiver operating characteristic curve of HMGB1 was 0.726 (95% CI 0.660-0.792) for PSD. Similar results were found when HMGB1 was analyzed as continuous variable. Furthermore, the optimal cutoff point of circulating HMGB1 levels was 8.6 ng/mL, with a sensitivity of 69.2% and a specificity of 73.9%.

conclusionsThis study demonstrated that higher HMGB1 levels in the acute phase of ischemic stroke were associated with increased risk of PSD.

Indexed as

Brain IschemiaHMGB1 ProteinIschemic StrokeStrokeBiomarkersDepressionFemaleHumansMaleMiddle AgedBiomarkersHMGB1 ProteinHMGB1 protein, humanBiomarkerDepressionHigh-mobility group box 1Ischemic stroke

Identifiers

PMID34800198

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.