Evidence map›Paper›PMID 34800193›Full record

ReviewMetabolomics : Official journal of the Metabolomic Society2021

What to feed or what not to feed-that is still the question.

James C Lech, Sophia I Dorfsman, Zoltán Répás, Tjaart P J Krüger, Ingrid Melinda Gyalai, László G Boros

Open access · hybridAbstract readReview
In one paragraph

Review in Metabolomics : Official journal of the Metabolomic Society, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Nutritional deuterium depletion and health: a scoping review.Metabolomics : Official journal of the Metabolomic Society · 2024
    Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 6 institutions in 5 countries.

James C LechFaculty of Science, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
Sophia I DorfsmanUniversity of Gastronomic Sciences, Bra, Italy.
Zoltán RépásInstitute of Food Science, Faculty of Agricultural and Food Sciences and Environmental Management, University of Debrecen, Debrecen, Hungary.
Tjaart P J KrügerDepartment of Physics, University of Pretoria, Pretoria, South Africa.
Ingrid Melinda GyalaiFaculty of Agriculture, University of Szeged, Hódmezővásárhely, Hungary.
László G BorosSiDMAP, LLC and the Deutenomics Science Institute, Los Angeles, CA, USA. contact@laszlogboros.com.ORCID 0000-0003-1211-9933
Amsterdam UMC Location University of Amsterdam · NLPhoenix Contact (United States) · USUniversity of Debrecen · HUUniversity of Gastronomic Sciences · ITUniversity of Pretoria · ZAUniversity of Szeged · HU

Funding

UCLA Center for Excellence in Pancreatic DiseasesP01AT003960 · NCCIH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GO, VAY LIANG W · 2007 to 2011
$5.6M
NCCIH NIH HHS P01 AT003960World Health Organization 001
6 · The paper itself

Abstract

introductionThis review addresses metabolic diversities after grain feeding of cattle using artificial total mixed ration (TMR), in place of pasture-based feeding.

objectivesTo determine how grain feeding impairs the deuterium-depleting functions of the anaplerotic mitochondrial matrix during milk and meat production.

methodsBased on published data we herein evaluate how grain-fed animals essentially follow a branched-chain amino acid and odd-chain fatty acid-based reductive carboxylation-dependent feedstock, which is also one of the mitochondrial deuterium-accumulating dysfunctions in human cancer.

resultsIt is now evident that food-based intracellular deuterium exchange reactions, especially that of glycogenic substrate oxidation, are significant sources of deuterium-enriched (

conclusionDevelopments in medical metabolomics, biochemistry and deutenomics, which is the science of biological deuterium fractionation and discrimination warrant urgent critical reviews in order to control the epidemiological scale of population diseases such as diabetes, obesity and cancer by a thorough understanding of how the compromised metabolic health of grain-fed dairy cows impacts human consumers.

Indexed as

Animal FeedLactationAnimalsCattleCrops, AgriculturalDietFemaleMetabolomicsPlants, Genetically ModifiedBranched chain amino acidsDeupletionDeutenomicsGrass feedingMitochondriaTotal mixed ration

Identifiers

PMID34800193
PMCPMC8605975
OpenAlexW3212526209

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.