Evidence map›Paper›PMID 34800156›Full record

SynthesisLung2021

Effects of Continuous Positive Airway Pressure on Cell Adhesion Molecules in Patients with Obstructive Sleep Apnea: A Meta-Analysis.

Zongsheng Tian, Jinyu Xiao, Jing Kang, Hongying Sun, Zhuangzhuang Mu, Dan Tong, Mingxian Li

Abstract readMeta-Analysis
PubMed Publisher
In one paragraph

Synthesis in Lung, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. A Review of a Recent Meta-Analysis Study on Obstructive Sleep Apnea.Journal of rhinology : official journal of the Korean Rhinologic Society · 2022
    Review
  8. Article
  9. Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Zongsheng TianDepartment of Respiratory, The First Hospital of Jilin University, 71 Xin Min Street, Changchun, 130021, Jilin, China.
Jinyu XiaoDepartment of Pediatric Neurology, The First Hospital of Jilin University, Changchun, 130021, Jilin, China.
Jing KangDepartment of Respiratory, The First Hospital of Jilin University, 71 Xin Min Street, Changchun, 130021, Jilin, China.
Hongying SunDepartment of Respiratory, The First Hospital of Jilin University, 71 Xin Min Street, Changchun, 130021, Jilin, China.
Zhuangzhuang MuDepartment of Respiratory, The First Hospital of Jilin University, 71 Xin Min Street, Changchun, 130021, Jilin, China.
Dan TongDepartment of Radiology, The First Hospital of Jilin University, 71 Xin Min Street, Changchun, 130021, Jilin, China. tongdan@jlu.edu.cn.
Mingxian LiDepartment of Respiratory, The First Hospital of Jilin University, 71 Xin Min Street, Changchun, 130021, Jilin, China. mingxian@jlu.edu.cn.ORCID 0000-0002-3433-9147
Jilin University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposePrevious studies have confirmed that patients with obstructive sleep apnea (OSA) have higher systemic inflammatory markers, including intercellular adhesion molecule-1(ICAM-1), vascular cell adhesion molecule-1(VCAM-1), and E-selectin compared to control subjects. However, the effects of continuous positive airway pressure (CPAP) therapy on circulating levels of ICAM-1, VCAM-1, and E-selectin in OSA patients remain inconsistent. Therefore, the primary purpose of the present meta-analysis is to estimate the effect of CPAP therapy on these cell adhesion molecules (CAMs) in patients with OSA.

methodsThe PubMed, Scopus, Embase, and Cochrane Library databases were searched. The overall effects were measured by the standardized mean difference (SMD) with a 95% confidence interval (CI). A random effects model or a fixed-effects model was used, depending on the heterogeneity of the studies.

resultsA total of 11 studies were included, comprising 650 OSA patients. The pooled results showed that CPAP therapy significantly decreased ICAM-1 (SMD =  - 0.283, 95% CI   - 0.464 to - 0.101, p = 0.002) and E-selectin levels (SMD =  - 0.349, 95% CI   - 0.566 to - 0.133, p = 0.002). In contrast, there was no significant improvement of VCAM-1 levels after CPAP treatment (SMD =  - 0.160, 95% CI   - 0.641 to 0.320, p = 0.513).

conclusionsOur meta-analysis demonstrated that CPAP treatment significantly decreased the circulating levels of ICAM-1 and E-selectin in OSA patients. Thus, ICAM-1 and E-selectin may be effective markers to evaluate CPAP therapy for reducing OSA cardiovascular risk in clinical practice.

Indexed as

Continuous Positive Airway PressureSleep Apnea, ObstructiveBiomarkersCell Adhesion MoleculesHumansVascular Cell Adhesion Molecule-1BiomarkersCell Adhesion MoleculesVascular Cell Adhesion Molecule-1Continuous positive airway pressureE-selectinIntercellular adhesion molecule-1Obstructive sleep apneaVascular cell adhesion molecule-1

Identifiers

PMID34800156
OpenAlexW3211735421

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.