Evidence map›Paper›PMID 34800139›Full record

ArticleGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie2022

Assessment of the microvasculature in poppers maculopathy.

T Hamann, M R J Wiest, M Brinkmann, M Toro, K Fasler, J Baur, K B Freund, Sandrine Zweifel

Open access · hybridAbstract read
In one paragraph

Article in Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 3 countries.

T Hamann *Department of Ophthalmology, University Hospital Zurich, Frauenklinikstrasse 24, Zurich, 8091, Switzerland.
M R J Wiest *Department of Ophthalmology, University Hospital Zurich, Frauenklinikstrasse 24, Zurich, 8091, Switzerland.
M BrinkmannDepartment of Ophthalmology, University Hospital Zurich, Frauenklinikstrasse 24, Zurich, 8091, Switzerland.
M ToroDepartment of Ophthalmology, University Hospital Zurich, Frauenklinikstrasse 24, Zurich, 8091, Switzerland.
K FaslerDepartment of Ophthalmology, University Hospital Zurich, Frauenklinikstrasse 24, Zurich, 8091, Switzerland.
J BaurDepartment of Ophthalmology, University Hospital Zurich, Frauenklinikstrasse 24, Zurich, 8091, Switzerland.
K B FreundVitreous Retina Macula Consultants of New York, New York, NY, USA.
Sandrine ZweifelDepartment of Ophthalmology, University Hospital Zurich, Frauenklinikstrasse 24, Zurich, 8091, Switzerland. sandrine.zweifel@usz.ch.
University Hospital of Zurich · CHNew York University · USUniversity of Zurich · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo investigate a possible microvascular component of poppers maculopathy (PMP) using optical coherence tomography angiography (OCTA).

methodsTwelve patients suffering from poppers maculopathy were included. Health records, optical coherence tomography (OCT), and OCTA data was gathered and compared to a healthy control group (HC). PMP lesion type was determined by manifestation in OCT. OCTA-based evaluation of retinal vascular plexus and choriocapillaris (CC) was executed. Vessel density (VD) and vessel length density (VLD) in superficial and deep capillary plexus (SCP, DCP), as well as flow deficits (FD), within the foveal avascular zone (FAZ) in CC were assessed.

resultsMedian age of PMP patients was 40 (min 24; max 64) years, all male. Eleven patients presented with ellipsoid zone-type lesions; one patient showed a vitelliform-type lesion. No qualitative microvascular changes between PMP patients and HC were identified. Quantitative values for VD and VLD of SCP and DCP did not differ in between the two groups. The analysis of FDs in CC showed no deviation from PMP patients to HC.

conclusionsNo vascular anomalies in qualitative and quantitative analysis in OCTA were detected in PMP patients. The constitution of the CC within FAZ of PMP patients does not differ from HC when assessed as FD.

Indexed as

Macula LuteaMacular DegenerationFluorescein AngiographyHumansMaleMicrovesselsMiddle AgedRetinal VesselsTomography, Optical CoherenceDrug toxicityMultimodal imagingOCT angiographyPoppers maculopathyRetinal toxicity

Identifiers

PMID34800139
PMCPMC8913571
OpenAlexW3214264196

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.