Evidence map›Paper›PMID 34800038›Full record

ArticleInternational journal of cancer2022

The development of "automated visual evaluation" for cervical cancer screening: The promise and challenges in adapting deep-learning for clinical testing: Interdisciplinary principles of automated visual evaluation in cervical screening.

Kanan T Desai, Brian Befano, Zhiyun Xue, Helen Kelly, Nicole G Campos, Didem Egemen, Julia C Gage, Ana-Cecilia Rodriguez, Vikrant Sahasrabuddhe, David Levitz and 5 more

Registry-linked trialAbstract read
In one paragraph

Article in International journal of cancer, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06815939 (Validation of a Lab-free Low-cost Screening Test for Prevention of Cervical Cancer), which is not on this map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06815939 narecruitingnot on this mapstarted 2025, after this paper: background citation

Validation of a Lab-free Low-cost Screening Test for Prevention of Cervical Cancer: Automated Visual Evaluation

TypeinterventionalSponsorDL AnalyticsRan2025 to 2026Enrolled10,000ConditionsHuman Papillomavirus (HPV), Cervical Intraepithelial Neoplasia, Uterine Cervical Neoplasms, Cervical CancersArmsHPV Test, EVA System, Visual Inspection with Acetic Acid (VIA), Automated Visual Evaluation (AVE), Image Capture with Mobile Phone
3 · Its place in the literature

Who cites it

38 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Kanan T DesaiDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, USA.ORCID 0000-0002-8992-5944
Brian BefanoInformation Management Services Inc., Calverton, Maryland, USA.ORCID 0000-0003-3614-210X
Zhiyun XueUS National Library of Medicine, Bethesda, Maryland, USA.
Helen KellyDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, USA.
Nicole G CamposCenter for Health Decision Science, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.ORCID 0000-0002-0840-4339
Didem EgemenDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, USA.
Julia C GageDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, USA.
Ana-Cecilia RodriguezDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, USA.
Vikrant SahasrabuddheDivision of Cancer Prevention, National Cancer Institute, Rockville, Maryland, USA.
David LevitzDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, USA.
Paul PearlmanCenter for Global Health, National Cancer Institute, Rockville, Maryland, USA.
Jose JeronimoDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, USA.
Sameer AntaniUS National Library of Medicine, Bethesda, Maryland, USA.
Mark SchiffmanDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, USA.
Silvia de SanjoséDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, USA.ORCID 0000-0002-5909-676X

Funding

Developing Data-Driven Cancer ResearchersT32CA009168 · NCI · UNIVERSITY OF WASHINGTON · PI STEPHEN M SCHWARTZ, MICHAEL Chiao-An WU · 1985 to 2026
$10.1M
Machine learning and artificial intelligence research for clinical medical image processingZIALM010018 · NLM · NATIONAL LIBRARY OF MEDICINE · PI ANTANI, SAMEER · 2021 to 2025
$9.0M
Intramural NIH HHS Z99 CA999999NCI NIH HHS T32 CA009168
6 · The paper itself

Abstract

There is limited access to effective cervical cancer screening programs in many resource-limited settings, resulting in continued high cervical cancer burden. Human papillomavirus (HPV) testing is increasingly recognized to be the preferable primary screening approach if affordable due to superior long-term reassurance when negative and adaptability to self-sampling. Visual inspection with acetic acid (VIA) is an inexpensive but subjective and inaccurate method widely used in resource-limited settings, either for primary screening or for triage of HPV-positive individuals. A deep learning (DL)-based automated visual evaluation (AVE) of cervical images has been developed to help improve the accuracy and reproducibility of VIA as assistive technology. However, like any new clinical technology, rigorous evaluation and proof of clinical effectiveness are required before AVE is implemented widely. In the current article, we outline essential clinical and technical considerations involved in building a validated DL-based AVE tool for broad use as a clinical test.

Indexed as

Deep LearningAlgorithmsEarly Detection of CancerFemaleHumansPapillomaviridaeReproducibility of ResultsUterine Cervical Neoplasmsartificial intelligencecervical cancer screeningclinical validationHPV testsvisual triage

Identifiers

PMID34800038
PMCPMC8732320

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.