Evidence map›Paper›PMID 34800010›Full record

ArticleEndocrinology, diabetes & metabolism2022

GAD65 autoantibodies and glucose tolerance in offspring born to women with and without type 1 diabetes (The EPICOM study).

Sine Knorr, Magnus C Lydolph, Birgitte Bytoft, Zuzana Lohse, Tine D Clausen, Rikke Beck Jensen, Peter Damm, Kurt Højlund, Dorte M Jensen, Claus H Gravholt

Open access · goldAbstract read
In one paragraph

Article in Endocrinology, diabetes & metabolism, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Oral GAD65-Microorganisms · 2026
    Article
  2. Circulating Cytokine Levels and Cardiovascular Disease Risk Profile in Young Adult Offspring of Women with Type 1 Diabetes.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2023
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Sine KnorrSteno Diabetes Center Aarhus, Aarhus University Hospital, Aarhus, Denmark.ORCID 0000-0001-6552-5340
Magnus C LydolphDepartment of Autoimmunology and Biomarkers, Statens Serum Institut, Copenhagen, Denmark.
Birgitte BytoftDepartment of Obstetrics, Center for Pregnant Women with Diabetes, Rigshospitalet, Copenhagen, Denmark.
Zuzana LohseSteno Diabetes Center Odense, Odense University Hospital, Odense, Denmark.
Tine D ClausenDepartment of Gynaecology and Obstetrics, Nordsjaellands Hospital, Hilleroed, Denmark.
Rikke Beck JensenDepartment of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark.
Peter DammDepartment of Autoimmunology and Biomarkers, Statens Serum Institut, Copenhagen, Denmark.
Kurt HøjlundSteno Diabetes Center Odense, Odense University Hospital, Odense, Denmark.
Dorte M JensenSteno Diabetes Center Odense, Odense University Hospital, Odense, Denmark.
Claus H GravholtDepartment of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark.
Steno Diabetes Centers · DKRigshospitalet · DKStatens Serum Institut · DKAarhus University Hospital · DKNordsjællands Hospital · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aims of this study were to examine presence of GAD65 autoantibodies (GAD65aab) in offspring born to women with type 1 diabetes (T1D) and controls and if more were GAD65aab-positive if diagnosed with diabetes or pre-diabetes. This EPICOM study is a prospective follow-up study focussing on pregnancies complicated by maternal T1D. The EPICOM study includes offspring (n = 278) born to mothers with pre-gestational T1D between 1993 and 1999 and matched un-exposed controls (n = 303). Age at the time of follow-up was 16.7 years (13.0-20.4 years). GAD65aab was measured using the Glutamic Acid Decarboxylase Autoantibody RIA kit from RSR

Indexed as

Diabetes Mellitus, Type 1AutoantibodiesFemaleFollow-Up StudiesGlucoseHumansPregnancyProspective StudiesAutoantibodiesGlucoseadolescentautoimmunitydiabetes mellitusGAD65 autoantibodiespregnancytype 1

Identifiers

PMID34800010
PMCPMC8754233
OpenAlexW3211920700

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.