ArticleCancer medicine2022
Incidence and survival of childhood central nervous system tumors in Denmark, 1997-2019.
Article in Cancer medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 35 citations in OpenAlex.
- Incidence patterns and temporal trends of childhood cancer in Germany, 1980-2019: Forty years of childhood cancer registration in Germany.International journal of cancer · 2026Article
- Global, regional, and national burden of brain and central nervous system cancer in children and adolescents, 1990-2021: A systematic analysis of the Global Burden of Disease study 2021.Pediatric investigation · 2025Article
- Impact of the COVID-19 pandemic on referral practices for pediatric central nervous system tumors: A Danish National Comparative Cohort Study.Neuro-oncology practice · 2025Article
- Impact of radiation dose on neurocognitive function and quality of life in long-term survivors of childhood brain tumour.Acta oncologica (Stockholm, Sweden) · 2025Article
- Early ophthalmological tumour signs and diagnostic interval in children with brain tumours.Eye (London, England) · 2025Article
- Long-term epidemiological trends in (primary) pediatric central nervous system tumors: a 25-year cohort analysis in Western Mexico.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2025Article
- Article
- Hjernetegn.dk-The Danish Central Nervous System Tumor Awareness Initiative Digital Decision Support Tool: Design and Implementation Report.JMIR medical informatics · 2024Article
- Assessment of the Milan Complexity Scale for prediction of postoperative morbidity in pediatric neuro-oncological surgery.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2023Article
- Molecular reclassification reveals low prevalence of germline predisposition in children with ependymoma.Acta neuropathologica communications · 2023Article
- Early disc degeneration in radiotherapy-treated childhood brain tumor survivors.BMC musculoskeletal disorders · 2023Article
- Neurocognitive function and health-related quality of life in a nationwide cohort of long-term childhood brain tumor survivors.Neuro-oncology practice · 2023Article
- CNS infection in children with brain tumors: adding ventriculostomy to brain tumor resection increases risk more than 20-fold.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2023Article
- Growth hormone deficiency in adult survivors of childhood brain tumors treated with radiation.Endocrine connections · 2023Article
- Musculoskeletal misdiagnoses in children with brain tumors: A nationwide, multicenter case-control study.PloS one · 2023Article
- Temozolomide Efficacy and Metabolism: The Implicit Relevance of Nanoscale Delivery Systems.Molecules (Basel, Switzerland) · 2022Review
- Incidence and survival of childhood central nervous system tumors in Denmark, 1997-2019.Cancer medicine · 2022Article
- The Role of Ketogenic Diet in the Treatment of Neuroblastoma.Integrative cancer therapiesReview
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIncidence rates in Denmark of central nervous system (CNS) tumors remain among the highest in the world. Survival rates, however, have improved in the past decades in high-income countries.
methodsWe analyzed incidence and survival of childhood CNS tumors in Denmark diagnosed from 1997 to 2019 based on data from the Danish Childhood Cancer Registry and information on histological types, tumor localization, and treatment from medical records.
resultsFrom 1997 to 2019, 949 children<15 years were diagnosed with a CNS tumor. Age-standardized incidence was 42.1 (95% CI, 39.4-44.6) per million person-years and stable during this period. Age-specific incidence for children aged 0-4 years was 47.7 per million. More than one-third (n = 374, 39.4%) were treated with surgery alone. Overall survival rates 5 and 10 years after diagnosis were 77.6% (95% CI, 74.7-80.2) and 74.7% (95% CI, 71.7-77.5). Five-year overall survival improved from 73.0% (95% CI, 68.9-76.7) in 1997-2008 to 83.2% (95% CI, 79.2-86.4) in 2009-2019 (p-value < 0.0001) in children aged 0-4 years (p = 0.0006).
conclusionIncidence rates are stable but remain among the highest in the world. Despite improved survival rates in recent years in younger children, some subtypes still have a poor prognosis.
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