Evidence map›Paper›PMID 34800004›Full record

ArticleAutism research : official journal of the International Society for Autism Research2022

Using the Clinical Global Impression scale to assess social communication change in minimally verbal children with autism spectrum disorder.

Christina Toolan, Alison Holbrook, Andrew Schlink, Stephanie Shire, Nancy Brady, Connie Kasari

2 registry-linked trialsAbstract read
In one paragraph

Article in Autism research : official journal of the International Society for Autism Research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01751698 nacompletednot on this map

Adaptive Interventions for Minimally Verbal Children With ASD in the Community

TypeinterventionalSponsorUniversity of California, Los AngelesRan2013 to 2017Enrolled192ConditionsAutismArmsJASP-EMT, DTT
NCT06763237 nanot yet recruitingnot on this mapstarted 2025, after this paper: background citation

Abdominal Transcutaneous Electrical Acupoint Stimulation on Children With Autism Spectrum Disorder: A Randomized Clinical Trial

TypeinterventionalSponsorFirst Affiliated Hospital Xi'an Jiaotong UniversityRan2025 to 2026Enrolled42ConditionsAutism Spectrum Disorder, Autism in ChildrenArmsabdominal transcutaneous electrical acupoint stimulation (abdominal TEAS)
3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Christina ToolanDepartment of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, California, USA.ORCID 0000-0001-7586-2287
Alison HolbrookSimons Foundation, New York, USA.
Andrew SchlinkDepartment of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, California, USA.
Stephanie ShireDepartment of Special Education and Clinical Sciences, University of Oregon, Eugene, Oregon, USA.
Nancy BradyDepartment of Speech Language Hearing Sciences and Disorders, University of Kansas, Lawrence, Kansas, USA.
Connie KasariDepartment of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, California, USA.

Funding

Adaptive Interventions for Minimally Verbal Children with ASD in the CommunityR01HD073975 · NICHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI KASARI, CONNIE L. · 2012 to 2016
$13.0M
Predicting and Otimizing Language Outcomes in Minimally Verbal Children with Autism Spectrum DisorderP50DC018006 · NIDCD · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI KASARI, CONNIE L., TAGER-FLUSBERG, HELEN · 2019 to 2023
$12.3M
The CCS: A Treatment Outcome Measure for Individuals with Severe IDR01HD076903 · NICHD · UNIVERSITY OF KANSAS LAWRENCE · PI BRADY, NANCY CAROLINE, FLEMING, KANDACE KAY · 2013 to 2017
$1.7M
NICHD NIH HHS R01 HD073975NICHD NIH HHS R01 HD076903NIDCD NIH HHS P50 DC018006
6 · The paper itself

Abstract

Assessing improvements in social communication behaviors in minimally verbal children with autism spectrum disorder (ASD) is often challenging. The Clinical Global Impression Scale (CGI) is a 7-point scale that has been adapted so that clinicians can easily and quickly rate social communication behaviors. The current study evaluated the CGI-Improvement (CGI-I) subscale as a measure of social communication change in minimally verbal children with ASD. The sample included 54 minimally verbal school-age children with ASD enrolled in a social communication intervention trial. CGIs were rated by interventionists and the study coordinator at baseline and at Week 6 of intervention, and were compared to scores on the Communication Complexity Scale (CCS). Results indicated that CGI ratings corresponded with CCS scores at baseline and Week 6. Children who were rated as more severe on social communication at baseline demonstrated lower complexity of communication compared to those who were rated as less severe. Those who demonstrated fast response to intervention at Week 6 showed greater improvement in their joint attention than those who were slower responders. These results provide support for the utility and validity of the CGI-I as a measure of social communication change in minimally verbal children. This study tested the CGI, a clinician rating scale, with a group of children with ASD with limited language who received intervention to improve social interactions and communication. Children's CGI ratings were comparable to other assessments in measuring social communication. The CGI may be a useful tool for those interested in quickly and easily tracking changes in children's social communication over the course of treatment. LAY SUMMARY: This study tested the Clinical Global Impression (CGI), a clinician rating scale, with a group of children with ASD with limited language who received intervention to improve social interactions and communication. Children's CGI ratings were comparable to other assessments in measuring social communication. The CGI may be a useful tool for those interested in quickly and easily tracking changes in children's social communication over the course of treatment.

Indexed as

Autism Spectrum DisorderAttentionChildCommunicationHumansSocial Behaviorassessmentautism spectrum disorderClinical Global Impression ScaleCommunication Complexity ScaleJASPERminimally verbalsocial communication

Identifiers

PMID34800004
PMCPMC8821201

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.