Evidence map›Paper›PMID 34799885›Full record

ArticleHead & neck2022

Prevalence of neurocognitive and perceived speech deficits in patients with head and neck cancer before treatment: Associations with demographic, behavioral, and disease-related factors.

Vitória Piai, Femke Jansen, Kristoffer Dahlslätt, Irma M Verdonck-de Leeuw, Judith Prins, René Leemans, Chris H J Terhaard, Johannes A Langendijk, Robert J Baatenburg de Jong, Johannes H Smit and 3 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Head & neck, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 1 country.

Vitória PiaiDepartment of Medical Psychology, Donders Centre for Medical Neuroscience, Radboud University Medical Center, Nijmegen, the Netherlands.ORCID 0000-0002-4860-5952
Femke JansenDepartment of Otolaryngology - Head and Neck Surgery, Cancer Center, Amsterdam UMC, Amsterdam, the Netherlands.
Kristoffer Dahlslätt
Irma M Verdonck-de LeeuwDepartment of Otolaryngology - Head and Neck Surgery, Cancer Center, Amsterdam UMC, Amsterdam, the Netherlands.ORCID 0000-0002-4507-4607
Judith PrinsDepartment of Medical Psychology, Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, the Netherlands.
René LeemansDepartment of Otolaryngology - Head and Neck Surgery, Cancer Center, Amsterdam UMC, Amsterdam, the Netherlands.
Chris H J TerhaardDepartment of Clinical, Neuro- and Developmental Psychology, Amsterdam Public Health Research Institute, Vrije Universiteit, Amsterdam, the Netherlands.
Johannes A LangendijkDepartment of Radiation Oncology, University Medical Centre Groningen, University of Groningen, Groningen, the Netherlands.
Robert J Baatenburg de JongDepartment of Otolaryngology - Head and Neck Surgery, Erasmus Cancer Institute, Erasmus MC, Rotterdam, the Netherlands.
Johannes H SmitDepartment of Psychiatry, Amsterdam Public Health, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.
Robert TakesDepartment of Otorhinolaryngology, Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, the Netherlands.ORCID 0000-0003-4784-0499
Roy P C KesselsDepartment of Medical Psychology, Donders Centre for Medical Neuroscience, Radboud University Medical Center, Nijmegen, the Netherlands.
NET-QUBIC ConsortiumProject Kubus, VU University Medical Center, Amsterdam, the Netherlands.
Radboud University Nijmegen · NLAmsterdam University Medical Centers · NLAmsterdam Neuroscience · NLErasmus MC Cancer Institute · NLUniversity Medical Center Groningen · NLUtrecht University · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNeurocognition and speech, relevant domains in head and neck cancer (HNC), may be affected pretreatment. However, the prevalence of pretreatment deficits and their possible concurrent predictors are poorly understood.

methodsUsing an HNC prospective cohort (Netherlands Quality of Life and Biomedical Cohort Study, N ≥ 444) with a cross-sectional design, we investigated the estimated prevalence of pretreatment deficits and their relationship with selected demographic, behavioral, and disease-related factors.

resultsUsing objective assessments, rates of moderate-to-severe neurocognitive deficit ranged between 4% and 8%. From patient-reported outcomes, 6.5% of patients reported high levels of cognitive failures and 46.1% reported speech deficits. Patient-reported speech functioning was worse in larynx compared to other subsites. Other nonspeech outcomes were unrelated to any variable. Patient-reported neurocognitive and speech functioning were modestly correlated, especially in the larynx group.

conclusionsThese findings indicate that a subgroup of patients with HNC shows pretreatment deficits, possibly accentuated in the case of larynx tumors.

Indexed as

Head and Neck NeoplasmsSpeechCohort StudiesCross-Sectional StudiesHumansPrevalenceProspective StudiesQuality of Lifefluencyhead and neck cancerneurocognitive assessmentpretreatment symptoms

Identifiers

PMID34799885
PMCPMC9299022
OpenAlexW3213840704

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.