ReviewNeurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics2021
Treatment and Evaluation Advances in Leprosy Neuropathy.
Review in Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 2 syntheses or guidelines pooled it, 83 citations in OpenAlex.
- Comparative analysis of the leprosy detection rate regarding its clinical spectrum through PCR using theFrontiers in microbiology · 2024Pooled it
- A systematic review of steroid use in peripheral nerve pathologies and treatment.Frontiers in neurology · 2024Pooled it
- A randomised controlled trial of raw honey for the healing of ulcers in leprosy in Nigeria.PLoS neglected tropical diseases · 2025Trial
- Factors associated with disability among patients with leprosy: a scoping review.BMC infectious diseases · 2026Article
- Surgical management of leprosy-associated neuropathy in Pakistan: Restoring function and reducing disability in the post-elimination era: A narrative review.Pakistan journal of medical sciences · 2026Review
- Diagnostic performance of peripheral nerve palpation compared with ultrasonography in leprosy neuropathy: A prospective real-world clinical evaluation.PLoS neglected tropical diseases · 2026Article
- Article
- Leprosy neuropathy and demyelinating impairment: How should we interpret this neurophysiological pattern?PloS one · 2026Observational
- Pathologic and Therapeutic Schwann Cells.Cells · 2025Review
- Article
- Time trend and identification of risk areas for physical disability due to leprosy in Brazil: An ecological study, 2001-2022.BMC infectious diseases · 2025Article
- Bullous Type 2 Lepra Reaction: A Rare and Significant Case Report.Clinical case reports · 2025Article
- Beyond Classic Leprosy: Exploring Atypical Manifestations and Their Diagnostic Challenges.Cureus · 2024Article
- Use of an inertial sensor and a force platform to assess static balance in participants affected by multibacillary leprosy.PLoS neglected tropical diseases · 2024Observational
- The marks of leprosy: disabilities caused by plantar lesions in discharged patients.Archives of dermatological research · 2024Article
- Neurological features of Hansen disease: a retrospective, multicenter cohort study.Scientific reports · 2024Article
- Neurologic Complications of Leprosy: A Case Series.Cureus · 2024Article
- Epidemiological, clinical, and geographical characterization of Leprosy in the County of Santarém-Pará: Insights for effective control and targeted intervention.PLoS neglected tropical diseases · 2024Article
- Case Report: Delayed Diagnosis of Leprosy-Related Neuropathic Ulcer, Insights from a Case of Delay to Diagnose across Four Clinical Settings.F1000Research · 2024Article
- Adenosine AFrontiers in pharmacology · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neuropathy and related disabilities are the major medical consequences of leprosy, which remains a global medical concern. Despite major advances in understanding the mechanisms of M. leprae entry into peripheral nerves, most aspects of the pathogenesis of leprosy neuropathy remain poorly understood. Sensory loss is characteristic of leprosy, but neuropathic pain is sometimes observed. Effective anti-microbial therapy is available, but neuropathy remains a problem especially if diagnosis and treatment are delayed. Currently there is intense interest in post-exposure prophylaxis with single-dose rifampin in endemic areas, as well as with enhanced prophylactic regimens in some situations. Some degree of nerve involvement is seen in all cases and neuritis may occur in the absence of leprosy reactions, but acute neuritis commonly accompanies both Type 1 and Type 2 leprosy reactions and may be difficult to manage. A variety of established as well as new methods for the early diagnosis and assessment of leprosy neuropathy are reviewed. Corticosteroids offer the primary treatment for neuritis and for subclinical neuropathy in leprosy, but success is limited if nerve function impairment is present at the time of diagnosis. A candidate vaccine has shown apparent benefit in preventing nerve injury in the armadillo model. The development of new therapeutics for leprosy neuropathy is greatly needed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.