Evidence map›Paper›PMID 34799839›Full record

ArticleDiabetes therapy : research, treatment and education of diabetes and related disorders2022

Gut Microbiome Activity Contributes to Prediction of Individual Variation in Glycemic Response in Adults.

Hal Tily, Eric Patridge, Ying Cai, Vishakh Gopu, Stephanie Gline, Matvey Genkin, Haely Lindau, Alisson Sjue, Iordan Slavov, Ally Perlina and 4 more

Open access · goldAbstract read
In one paragraph

Article in Diabetes therapy : research, treatment and education of diabetes and related disorders, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.

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  13. Personalized glucose prediction usingFrontiers in nutrition · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 1 institution in 1 country.

Hal TilyViome Research Institute, Viome Life Sciences, Inc, New York City, USA.ORCID http://orcid.org/0000-0002-7419-3234
Eric PatridgeViome Research Institute, Viome Life Sciences, Inc, New York City, USA.ORCID http://orcid.org/0000-0002-8638-3043
Ying CaiViome Research Institute, Viome Life Sciences, Inc, New York City, USA.
Vishakh GopuViome Research Institute, Viome Life Sciences, Inc, New York City, USA.
Stephanie GlineViome Research Institute, Viome Life Sciences, Inc, New York City, USA.
Matvey GenkinViome Research Institute, Viome Life Sciences, Inc, New York City, USA.
Haely LindauViome Research Institute, Viome Life Sciences, Inc, Seattle, USA.
Alisson SjueViome Research Institute, Viome Life Sciences, Inc, Seattle, USA.
Iordan SlavovViome Research Institute, Viome Life Sciences, Inc, New York City, USA.
Ally PerlinaViome Research Institute, Viome Life Sciences, Inc, Seattle, USA.
Niels KlitgordViome Research Institute, Viome Life Sciences, Inc, Seattle, USA.
Helen MessierViome Research Institute, Viome Life Sciences, Inc, Seattle, USA.
Momchilo VuyisichViome Research Institute, Viome Life Sciences, Inc, Seattle, USA.ORCID http://orcid.org/0000-0002-0531-6755
Guruduth BanavarViome Research Institute, Viome Life Sciences, Inc, New York City, USA. guru@viome.com.ORCID http://orcid.org/0000-0002-4170-7841
VinTech (United States) · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Limiting postprandial glycemic response (PPGR) is an important intervention in reducing the risk of chronic metabolic diseases and has been shown to impart significant health benefits in people with elevated levels of blood sugar. In this study, we collected gut microbiome activity data by assessing the metatranscriptome, and we measured the glycemic responses of 550 adults who consumed more than 30,000 meals, collectively, from omnivore or vegetarian/gluten-free diets. We demonstrate that gut microbiome activity, anthropometric factors, and food macronutrients modulate individual variation in glycemic response. We employ two predictive models, including a mixed-effects linear regression model (R = 0.77) and a gradient boosting machine model (R

Indexed as

Artificial intelligenceGlycemic responseGut microbiomeMachine learningMetatranscriptomePostprandial blood glucose

Identifiers

PMID34799839
PMCPMC8776936
OpenAlexW3212843907

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.