Evidence map›Paper›PMID 34799788›Full record

Observational studyHeart and vessels2022

Outcomes of hypertrophic cardiomyopathy in Japanese children: a retrospective cohort study.

Hiroki Mori, Tadahiro Yoshikawa, Hitomi Kimura, Hiroshi Ono, Hitoshi Kato, Yasuo Ono, Masaki Nii, Takahiro Shindo, Ryo Inuzuka, Hitoshi Horigome and 6 more

Abstract readMulticenter StudyObservational Study
PubMed Publisher
In one paragraph

Observational study in Heart and vessels, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.5field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 10 institutions in 1 country.

Hiroki MoriDepartment of Pediatric Cardiology, Tokyo Women's Medical University, Tokyo, Japan.
Tadahiro YoshikawaDivision of Pediatric Cardiology, Sakakibara Heart Institute, Tokyo, Japan.
Hitomi KimuraDivision of Pediatric Cardiology, Sakakibara Heart Institute, Tokyo, Japan.
Hiroshi OnoDivision of Cardiology, National Center for Child Health and Development, Tokyo, Japan.
Hitoshi KatoDivision of Cardiology, National Center for Child Health and Development, Tokyo, Japan.
Yasuo OnoDivision of Cardiology, Shizuoka Children's Hospital, Shizuoka, Japan.
Masaki NiiDivision of Cardiology, Shizuoka Children's Hospital, Shizuoka, Japan.
Takahiro ShindoDepartment of Pediatrics, The University of Tokyo, Tokyo, Japan.
Ryo InuzukaDepartment of Pediatrics, The University of Tokyo, Tokyo, Japan.
Hitoshi HorigomeDepartment of Pediatrics, University of Tsukuba, Tsukuba, Japan.
Masaru MiuraDivision of Cardiology, Tokyo Metropolitan Children's Medical Center, Tokyo, Japan.
Keiichi HironoDepartment of Pediatrics, University of Toyama, Toyama, Japan.
Tomio KobayashiDivision of Cardiology, Gunma Children's Medical Center, Shibukawa, Gunma, Japan.
Shigetoyo KogakiDepartment of Pediatrics, Osaka University, Suita, Osaka, Japan.
Yoshiyuki FurutaniDepartment of Pediatric Cardiology, Tokyo Women's Medical University, Tokyo, Japan.
Toshio NakanishiDepartment of Pediatric Cardiology, Tokyo Women's Medical University, Tokyo, Japan. pnakanis@gmail.com.ORCID http://orcid.org/0000-0002-7374-9317
Sakakibara Hospital · JPNational Center For Child Health and Development · JPShizuoka Children's Hospital · JPThe University of Tokyo · JPTokyo Women's Medical University · JPGunma Children's Medical Center · JPThe University of Osaka · JPTokyo Metropolitan Children's Medical Center · JPUniversity of Toyama · JPUniversity of Tsukuba · JP

Funding

Health and Labor Sciences Research Grant from the Ministry of Health and Labor (Grant number H25-102)
6 · The paper itself

Abstract

There has been no multicenter study on the prognosis of pediatric hypertrophic cardiomyopathy (HCM) in Japan. Therefore, we conducted a retrospective multicenter observational study on the long-term survival rate in patients diagnosed with HCM under the age of 18 between 1990 and 2014. Twenty institutions participated. A total of 180 patients were identified. The median age at diagnosis was 5.8 years old and median duration of observation was 8.3 years. Although six patients (3%) deteriorated into the dilated phase of HCM, no patient received heart transplantation. Freedom from death at 1, 5, 10, and 20 years were 97%, 92%, 84%, and 80%, respectively. There were 26 deaths. Among them, 11 patients died suddenly, presumably due to arrhythmia, and 15 patients died of heart failure. The presence of heart failure symptoms and a greater cardiothoracic ratio were significant risk factors for heart failure-related death. There were no significant risk factors identified for arrhythmia-related death. In conclusion, the prognosis of pediatric HCM in Japan is good and similar to those reported in population-based studies in the United States and Australia. Significant risk factors for heart failure-related death were identified in pediatric patients with HCM in Japan.

Indexed as

Cardiomyopathy, HypertrophicHeart FailureArrhythmias, CardiacChildChild, PreschoolHumansJapanRetrospective StudiesChildrenHypertrophic cardiomyopathyMortalityRisk factors

Identifiers

PMID34799788
OpenAlexW3211639928

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.