ReviewNature reviews. Microbiology2022
Ecology, evolution and spillover of coronaviruses from bats.
Review in Nature reviews. Microbiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 163 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
163 citing papers in PubMed, 3 syntheses or guidelines pooled it, 284 citations in OpenAlex.
- Impacts of bat use of anthropogenic structures on bats and humans.Conservation biology : the journal of the Society for Conservation Biology · 2026Pooled it
- Pooled it
- Coronavirus sampling and surveillance in bats from 1996-2019: a systematic review and meta-analysis.Nature microbiology · 2023Pooled it
- Seasonal human coronavirus humoral responses in AZD1222 (ChaAdOx1 nCoV-19) COVID-19 vaccinated adults reveal limited cross-immunity.Frontiers in immunology · 2024Trial
- Hitting Coronaviruses Where It Hurts: Antiviral Strategies Targeting Viral Proteins.ChemMedChem · 2026Review
- Novel AfricanJournal of virology · 2026Article
- Porcine coronavirus promotes NLRP3 inflammasome activation during virus-induced neuroinflammation.mBio · 2026Article
- A divergent betacoronavirus with a functional furin cleavage site in South American bats.Nature communications · 2026Article
- Atlas of gross, histologic, and immunohistologic anatomy of the lymphoid system in Egyptian rousettes (Rousettus aegyptiacus).Veterinary research · 2026Article
- Drivers of Viral Spillover: An Examination of How Pathogens Spread.Pathogens (Basel, Switzerland) · 2026Review
- Structural dynamics and allosteric communication of a SARS-like bat coronavirus spike glycoprotein.Biophysical journal · 2026Article
- Detection and characterization of a MERS-related coronavirus (Betacoronavirus cameli) in velvety free-tailed bats (Molossus molossus, Mammalia) captured in Southern Brazil.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2026Article
- Addressing the zoonotic threat of merbecoviruses.Nature microbiology · 2026Review
- From concept to capability: CBRNE-grade, equity-first benchmarks for preventing HKU5-CoV-2 spillover.Infectious diseases & immunity · 2026Article
- Extra gene coding capacity of SARS-CoV-2 provides a virus engineering platform for in vitro and in vivo applications.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Sequencing of Betacoronavirus erinacei from faeces of pet hedgehogs demonstrates a continuity of MERS-CoV like viruses in European and Eurasian hedgehog species.One health (Amsterdam, Netherlands) · 2026Article
- Leveraging organoid models to understand mechanisms of viral infections and immunity in bats.Disease models & mechanisms · 2026Review
- Coronavirus diversity and SARS-CoV-2 exposure at the wildlife-human interface in Northern Italy.Virology journal · 2026Article
- Review
- Host-virus association databases as tools for understanding viral spillover at varying scales.PLoS neglected tropical diseases · 2026Article
103 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
29 authors at 10 institutions in 3 countries.
Funding
Abstract
In the past two decades, three coronaviruses with ancestral origins in bats have emerged and caused widespread outbreaks in humans, including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Since the first SARS epidemic in 2002-2003, the appreciation of bats as key hosts of zoonotic coronaviruses has advanced rapidly. More than 4,000 coronavirus sequences from 14 bat families have been identified, yet the true diversity of bat coronaviruses is probably much greater. Given that bats are the likely evolutionary source for several human coronaviruses, including strains that cause mild upper respiratory tract disease, their role in historic and future pandemics requires ongoing investigation. We review and integrate information on bat-coronavirus interactions at the molecular, tissue, host and population levels. We identify critical gaps in knowledge of bat coronaviruses, which relate to spillover and pandemic risk, including the pathways to zoonotic spillover, the infection dynamics within bat reservoir hosts, the role of prior adaptation in intermediate hosts for zoonotic transmission and the viral genotypes or traits that predict zoonotic capacity and pandemic potential. Filling these knowledge gaps may help prevent the next pandemic.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.