Evidence map›Paper›PMID 34799653›Full record

ArticleScientific reports2021

Impact of the molar activity and PSMA expression level on [

Sarah Piron, Jeroen Verhoeven, Emma De Coster, Benedicte Descamps, Ken Kersemans, Leen Pieters, Anne Vral, Christian Vanhove, Filip De Vos

Abstract read
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. [European journal of nuclear medicine and molecular imaging · 2026
    Article
  2. Article
  3. Structure-activity relationship ofEJNMMI radiopharmacy and chemistry · 2025
    Article
  4. Synthesis of DOTA-BasedMethods and protocols · 2025
    Article
  5. JHU-2545 preferentially shields salivary glands and kidneys during PSMA-targeted imaging.European journal of nuclear medicine and molecular imaging · 2025
    Article
  6. Review
  7. Review
  8. Review
  9. Influence of the Molar Activity ofPharmaceuticals (Basel, Switzerland) · 2023
    Article
  10. Review
  11. Preclinical comparative study of [Scientific reports · 2022
    Article
  12. OptimizedPharmaceuticals (Basel, Switzerland) · 2022
    Article
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Sarah PironLaboratory for Radiopharmacy, Ghent University, Ghent, Belgium. sarah.piron@ugent.be.ORCID 0000-0002-5543-7678
Jeroen VerhoevenDepartment of Diagnostic Sciences, Ghent University, Ghent, Belgium.
Emma De CosterLaboratory for Radiopharmacy, Ghent University, Ghent, Belgium.
Benedicte DescampsDepartment of Electronics and Information Systems, IBiTech-MEDISIP, Ghent University, Ghent, Belgium.
Ken KersemansDepartment of Medical Imaging, Ghent University Hospital, Ghent, Belgium.
Leen PietersDepartment of Human Structure and Repair, Ghent University, Ghent, Belgium.
Anne VralDepartment of Human Structure and Repair, Ghent University, Ghent, Belgium.
Christian VanhoveDepartment of Electronics and Information Systems, IBiTech-MEDISIP, Ghent University, Ghent, Belgium.
Filip De VosLaboratory for Radiopharmacy, Ghent University, Ghent, Belgium.

Funding

Fonds Wetenschappelijk Onderzoek TBM T001517
6 · The paper itself

Abstract

This two-part preclinical study aims to evaluate prostate specific membrane antigen (PSMA) as a valuable target for expression-based imaging applications and to determine changes in target binding in function of varying apparent molar activities (MA

Indexed as

Gene Expression Regulation, NeoplasticAnimalsCell Line, TumorGlutamate Carboxypeptidase IIGlutaratesHumansMaleMembrane GlycoproteinsMiceMice, Inbred NODMice, SCIDNeoplasm TransplantationPhosphinic AcidsPositron-Emission TomographyPositron Emission Tomography Computed TomographyProstatic Neoplasms(18)F-PSMA-11Glutamate Carboxypeptidase IIGlutaratesMembrane GlycoproteinsPhosphinic AcidsProteasome Endopeptidase ComplexPSMA1 protein, humanPSMA protein, mouseRadiopharmaceuticals

Identifiers

PMID34799653
PMCPMC8604919

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.