Evidence map›Paper›PMID 34799640›Full record

ArticleScientific reports2021

Measurements of spontaneous CFTR-mediated ion transport without acute channel activation in airway epithelial cultures after modulator exposure.

Heidi J Nick, Pamela L Zeitlin, Sangya Yadav, Preston E Bratcher

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.4field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. VX-770, CInternational journal of molecular sciences · 2025
    Article
  3. Article
  4. Net benefit of ivacaftor during prolonged tezacaftor/elexacaftor exposure in vitro.Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society · 2022
    Article
  5. Assays of CFTR Function In Vitro, Ex Vivo and In Vivo.International journal of molecular sciences · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Heidi J Nick *Department of Pediatrics, National Jewish Health, 1400 Jackson Street, Denver, CO, 80206, USA.
Pamela L Zeitlin *Department of Pediatrics, National Jewish Health, 1400 Jackson Street, Denver, CO, 80206, USA.
Sangya YadavDepartment of Pediatrics, National Jewish Health, 1400 Jackson Street, Denver, CO, 80206, USA.
Preston E BratcherDepartment of Pediatrics, National Jewish Health, 1400 Jackson Street, Denver, CO, 80206, USA. BratcherP@NJHealth.org.
National Jewish Health · USUniversity of Colorado Anschutz Medical Campus · USUniversity of Colorado Denver · US

Funding

Contribution of pulmonary ionocytes and neuroendocrine cells to ion transport-mediated airway surface liquid maintenanceR01HL155325 · NHLBI · NATIONAL JEWISH HEALTH · PI BRATCHER, PRESTON E · 2021 to 2025
$2.3M
Cystic Fibrosis Foundation BRATCH16I0NHLBI NIH HHS R01 HL155325NIH HHS R01HL155325
6 · The paper itself

Abstract

Quantitation of CFTR function in vitro is commonly performed by acutely stimulating then inhibiting ion transport through CFTR and measuring the resulting changes in transepithelial voltage (V

Indexed as

1-Methyl-3-isobutylxanthineAminophenolsAminopyridinesAnimalsBenzodioxolesBiological ProductsCells, CulturedColforsinCystic FibrosisCystic Fibrosis Transmembrane Conductance RegulatorElectrophysiologyEpithelial CellsEpitheliumGenotypeHumansMice1-Methyl-3-isobutylxanthineAminophenolsAminopyridinesBenzodioxolesBiological ProductsCFTR protein, humanColforsinCystic Fibrosis Transmembrane Conductance Regulatorcystic fibrosis transmembrane conductance regulator delta F508ivacaftorlumacaftorQuinolones

Identifiers

PMID34799640
PMCPMC8605007
OpenAlexW3214559875

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.