Evidence map›Paper›PMID 34799599›Full record

ArticleNature communications2021

A national cohort study (2000-2018) of long-term air pollution exposure and incident dementia in older adults in the United States.

Liuhua Shi, Kyle Steenland, Haomin Li, Pengfei Liu, Yuhan Zhang, Robert H Lyles, Weeberb J Requia, Sindana D Ilango, Howard H Chang, Thomas Wingo and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 125 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
125citing papers in PubMed, 6 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

125 citing papers in PubMed, 6 syntheses or guidelines pooled it.

  1. Pooled it
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  7. Article
  8. Review
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  11. Revisiting 'environmental effects': Directions for multidisciplinary investigations of air quality and psychopathology.Clinical psychological science : a journal of the Association for Psychological Science · 2026
    Article
  12. Review
  13. 2-aminobutyrate mediates the impact of air pollution on blood biomarkers of Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
  14. Article
  15. Review
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65 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Liuhua Shi *Gangarosa Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, GA, USA. liuhua.shi@emory.edu.ORCID 0000-0001-8165-4644
Kyle Steenland *Gangarosa Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, GA, USA.
Haomin LiDepartment of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA.
Pengfei LiuSchool of Earth and Atmospheric Sciences, Georgia Institute of Technology, Atlanta, GA, USA.
Yuhan ZhangDepartment of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA.
Robert H LylesDepartment of Biostatistics and Bioinformatics, Rollins School of Public Health, Emory University, Atlanta, GA, USA.
Weeberb J RequiaSchool of Public Policy and Government, Fundação Getúlio Vargas, Brasília, DF, Brazil.ORCID 0000-0002-7564-3364
Sindana D IlangoDepartment of Epidemiology, School of Public Health, University of Washington, Seattle, WA, USA.
Howard H ChangGangarosa Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, GA, USA.
Thomas WingoDepartment of Neurology and Human Genetics, School of Medicine, Emory University, Atlanta, GA, USA.ORCID 0000-0002-7679-6282
Rodney J WeberSchool of Earth and Atmospheric Sciences, Georgia Institute of Technology, Atlanta, GA, USA.
Joel SchwartzDepartment of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA.ORCID 0000-0001-6168-378X

Funding

The Emory Alzheimer's Disease CenterP50AG025688 · NIA · EMORY UNIVERSITY · PI WALKER, LARY C · 2005 to 2019
$25.7M
Pilot Project ProgramP30ES019776 · NIEHS · EMORY UNIVERSITY · PI William Michael Caudle · 2013 to 2026
$22.6M
Biostatistics, Epidemiologic & Bioinformatic Training in Environmental HealthT32ES015459 · NIEHS · UNIVERSITY OF WASHINGTON · PI June T. Spector · 2009 to 2026
$10.6M
Air Pollution and Alzheimer's Disease and Related Dementias: A National StudyR01AG074357 · NIA · EMORY UNIVERSITY · PI STEENLAND, NELSON K · 2021 to 2025
$3.4M
NIA NIH HHS P50 AG025688NIA NIH HHS R01 AG074357NIEHS NIH HHS P30 ES019776NIEHS NIH HHS T32 ES015459
6 · The paper itself

Abstract

Air pollution may increase risk of Alzheimer's disease and related dementias (ADRD) in the U.S., but the extent of this relationship is unclear. Here, we constructed two national U.S. population-based cohorts of those aged ≥65 from the Medicare Chronic Conditions Warehouse (2000-2018), combined with high-resolution air pollution datasets, to investigate the association of long-term exposure to ambient fine particulate matter (PM

Indexed as

AgedAged, 80 and overAir PollutantsAir PollutionDementiaEnvironmental ExposureEnvironmental MonitoringFemaleFollow-Up StudiesHumansIncidenceMaleParticulate MatterRisk FactorsUnited StatesAir PollutantsParticulate Matter

Identifiers

PMID34799599
PMCPMC8604909

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.