ArticleScientific reports2021
Large-scale genetic investigation reveals genetic liability to multiple complex traits influencing a higher risk of ADHD.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 22 citations in OpenAlex.
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- Shared genetic architecture between Parkinson's disease and self-reported sleep-related traits implicates theSleep advances : a journal of the Sleep Research Society · 2026Article
- Genetics of Major Depressive Disorder in a Homogeneous Population with Uniform Phenotyping.Research square · 2025Article
- Multivariate genome-wide association analysis of dyslexia and quantitative reading skill improves gene discovery.Translational psychiatry · 2025Article
- Unraveling ADHD: genes, co-occurring traits, and developmental dynamics.Life science alliance · 2025Article
- Genomic analysis of intracranial and subcortical brain volumes yields polygenic scores accounting for variation across ancestries.Nature genetics · 2024Article
- Genomic analysis of intracranial and subcortical brain volumes yields polygenic scores accounting for variation across ancestries.medRxiv : the preprint server for health sciences · 2024Article
- Investigating the Shared Genetic Etiology Between Parkinson's Disease and Depression.Journal of Parkinson's disease · 2024Article
- Prevalence of somatic diseases in adults with attention deficit hyperactivity disorder in Japan is highest in people aged ≥40 years with mental disorders: a cross-sectional study of a Japanese health insurance claims database.Frontiers in psychiatry · 2024Article
- Discontinuation of antidepressant treatment: a retrospective cohort study on more than 20,000 participants.Annals of general psychiatry · 2023Article
- Shared molecular genetic factors influence subcortical brain morphometry and Parkinson's disease risk.NPJ Parkinson's disease · 2023Article
- Shared genetics and bidirectional causal relationships between type 2 diabetes and attention-deficit/hyperactivity disorder.General psychiatry · 2023Article
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
Attention Deficit-Hyperactivity Disorder (ADHD) is a complex psychiatric and neurodevelopmental disorder that develops during childhood and spans into adulthood. ADHD's aetiology is complex, and evidence about its cause and risk factors is limited. We leveraged genetic data from genome-wide association studies (GWAS) and performed latent causal variable analyses using a hypothesis-free approach to infer causal associations between 1387 complex traits and ADHD. We identified 37 inferred potential causal associations with ADHD risk. Our results reveal that genetic variants associated with iron deficiency anemia (ICD10), obesity, type 2 diabetes, synovitis and tenosynovitis (ICD10), polyarthritis (ICD10), neck or shoulder pain, and substance use in adults display partial genetic causality on ADHD risk in children. Genetic variants associated with ADHD have a partial genetic causality increasing the risk for chronic obstructive pulmonary disease and carpal tunnel syndrome. Protective factors for ADHD risk included genetic variants associated with the likelihood of participating in socially supportive and interactive activities. Our results show that genetic liability to multiple complex traits influences a higher risk for ADHD, highlighting the potential role of cardiometabolic phenotypes and physical pain in ADHD's aetiology. These findings have the potential to inform future clinical studies and development of interventions.
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