Evidence map›Paper›PMID 34799586›Full record

ArticleNature communications2021

BST1 regulates nicotinamide riboside metabolism via its glycohydrolase and base-exchange activities.

Keisuke Yaku, Sailesh Palikhe, Hironori Izumi, Tomoyuki Yoshida, Keisuke Hikosaka, Faisal Hayat, Mariam Karim, Tooba Iqbal, Yasuhito Nitta, Atsushi Sato and 4 more

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed
8.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 75 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Trial
  4. Trial
  5. Article
  6. Skin Cancer Prevention and Antiaging: Role of Nicotinamide.International journal of molecular sciences · 2026
    Review
  7. Reduced Versus Oxidized NADFASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Article
  8. Article
  9. Article
  10. NADNature metabolism · 2025
    Review
  11. Review
  12. Article
  13. Article
  14. Deciphering the role of nicotinamide metabolism and melanin-related genes in acute myocardial infarction: a machine learning approach integrating bioinformatics analysis.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2025
    Article
  15. The role of NADnpj metabolic health and disease · 2025
    Review
  16. Article
  17. Article
  18. Protein Acetylation and NAD+ Homeostasis in Aging Muscle.Advances in experimental medicine and biology · 2025
    Review
  19. Article
  20. Regulation of and challenges in targeting NADNature reviews. Molecular cell biology · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 2 countries.

Keisuke Yaku *Department of Molecular and Medical Pharmacology, Faculty of Medicine, University of Toyama, 2630 Sugitani, Toyama, Toyama, 930-0194, Japan.
Sailesh Palikhe *Department of Molecular and Medical Pharmacology, Faculty of Medicine, University of Toyama, 2630 Sugitani, Toyama, Toyama, 930-0194, Japan.
Hironori IzumiDepartment of Molecular Neuroscience, Faculty of Medicine, University of Toyama, 2630 Sugitani, Toyama, Toyama, 930-0194, Japan.
Tomoyuki YoshidaDepartment of Molecular Neuroscience, Faculty of Medicine, University of Toyama, 2630 Sugitani, Toyama, Toyama, 930-0194, Japan.ORCID http://orcid.org/0000-0002-8476-3798
Keisuke HikosakaDepartment of Molecular and Medical Pharmacology, Faculty of Medicine, University of Toyama, 2630 Sugitani, Toyama, Toyama, 930-0194, Japan.
Faisal HayatMitchell Cancer Institute, Department of Pharmacology, University of South Alabama, 1660 Springhill Avenue, Mobile, AL, 36693, USA.
Mariam KarimDepartment of Molecular and Medical Pharmacology, Faculty of Medicine, University of Toyama, 2630 Sugitani, Toyama, Toyama, 930-0194, Japan.
Tooba IqbalDepartment of Molecular and Medical Pharmacology, Faculty of Medicine, University of Toyama, 2630 Sugitani, Toyama, Toyama, 930-0194, Japan.
Yasuhito NittaDepartment of Molecular and Medical Pharmacology, Faculty of Medicine, University of Toyama, 2630 Sugitani, Toyama, Toyama, 930-0194, Japan.
Atsushi SatoSchool of Bioscience and Biotechnology, Tokyo University of Technology, 1404-1 Katakuramachi, Hachioji, Tokyo, 192-0982, Japan.
Marie E MigaudMitchell Cancer Institute, Department of Pharmacology, University of South Alabama, 1660 Springhill Avenue, Mobile, AL, 36693, USA.
Katsuhiko IshiharaDepartment of Immunology and Molecular Genetics, Kawasaki Medical University, 577 Matsushima, Kurashiki, Okayama, 701-0192, Japan.ORCID http://orcid.org/0000-0002-2826-5188
Hisashi MoriDepartment of Molecular Neuroscience, Faculty of Medicine, University of Toyama, 2630 Sugitani, Toyama, Toyama, 930-0194, Japan.ORCID http://orcid.org/0000-0001-9743-2456
Takashi NakagawaDepartment of Molecular and Medical Pharmacology, Faculty of Medicine, University of Toyama, 2630 Sugitani, Toyama, Toyama, 930-0194, Japan. nakagawa@med.u-toyama.ac.jp.ORCID http://orcid.org/0000-0001-5539-7605
University of Toyama · JPUSA Mitchell Cancer Institute · USKawasaki Medical School · JPTokyo University of Technology · JPToyama University Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nicotinamide riboside (NR) is one of the orally bioavailable NAD

Indexed as

A549 CellsAdministration, OralADP-ribosyl CyclaseAgingAnimalsAntigens, CDDietary SupplementsGastrointestinal MicrobiomeGlycoside HydrolasesGPI-Linked ProteinsHumansIntestinal MucosaIntestine, SmallMiceMice, KnockoutNiacinADP-ribosyl CyclaseADP-ribosyl cyclase 2Antigens, CDGlycoside HydrolasesGPI-Linked ProteinsNiacinNiacinamidenicotinamide-beta-ribosidenicotinate phosphoribosyltransferasePentosyltransferasesPyridinium Compounds

Identifiers

PMID34799586
PMCPMC8604996
OpenAlexW3213809584

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.