Evidence map›Paper›PMID 34799454›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2021

The small molecule Zaractin activates ZAR1-mediated immunity in

Derek Seto, Madiha Khan, D Patrick Bastedo, Alexandre Martel, Trinh Vo, David Guttman, Rajagopal Subramaniam, Darrell Desveaux

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Article
  6. ZAR1: Guardian of plant kinases.Frontiers in plant science · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Derek SetoDepartment of Cell and Systems Biology, University of Toronto, Toronto, ON M5S 3B2, Canada.ORCID 0000-0002-0981-9691
Madiha KhanDepartment of Cell and Systems Biology, University of Toronto, Toronto, ON M5S 3B2, Canada.
D Patrick BastedoDepartment of Cell and Systems Biology, University of Toronto, Toronto, ON M5S 3B2, Canada.ORCID 0000-0002-7698-7994
Alexandre MartelDepartment of Cell and Systems Biology, University of Toronto, Toronto, ON M5S 3B2, Canada.
Trinh VoDepartment of Cell and Systems Biology, University of Toronto, Toronto, ON M5S 3B2, Canada.ORCID 0000-0002-4225-0900
David GuttmanDepartment of Cell and Systems Biology, University of Toronto, Toronto, ON M5S 3B2, Canada.
Rajagopal SubramaniamDepartment of Cell and Systems Biology, University of Toronto, Toronto, ON M5S 3B2, Canada; rajagopal.subramaniam@agr.gc.ca darrell.desveaux@utoronto.ca.ORCID 0000-0002-4726-3612
Darrell DesveauxDepartment of Cell and Systems Biology, University of Toronto, Toronto, ON M5S 3B2, Canada; rajagopal.subramaniam@agr.gc.ca darrell.desveaux@utoronto.ca.ORCID 0000-0003-4270-2791
University of Toronto · CAAgriculture and Agri-Food Canada · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pathogenic effector proteins use a variety of enzymatic activities to manipulate host cellular proteins and favor the infection process. However, these perturbations can be sensed by nucleotide-binding leucine-rich-repeat (NLR) proteins to activate effector-triggered immunity (ETI). Here we have identified a small molecule (Zaractin) that mimics the immune eliciting activity of the

Indexed as

ArabidopsisArabidopsis ProteinsBacterial ProteinsCarrier ProteinsIntracellular Signaling Peptides and ProteinsNLR ProteinsPlant DiseasesPlant ImmunityProtein BindingPseudomonas syringaeSmall Molecule LibrariesArabidopsis ProteinsBacterial ProteinsCarrier ProteinsIntracellular Signaling Peptides and ProteinsNLR ProteinsSmall Molecule LibrariesZAR1 protein, ArabidopsisArabidopsischemical biology: zaractinimmunityPseudomonas syringaetype III effector

Identifiers

PMID34799454
PMCPMC8617420
OpenAlexW3211532226

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.