Evidence map›Paper›PMID 34799448›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2021

The E3 ubiquitin ligase adaptor

Jongbin Lee, Chunghun Lim, Tae Hee Han, Tomas Andreani, Matthew Moye, Jack Curran, Eric Johnson, William L Kath, Casey O Diekman, Bridget C Lear and 1 more

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.8field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. Sleep regulation inFrontiers in neuroscience · 2026
    Review
  2. A circadian clock output functions independently of phyB to sustain daytime PIF3 degradation.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  3. Article
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

Jongbin LeeDepartment of Neurobiology, Northwestern University, Evanston, IL 60208.ORCID 0000-0002-5868-7437
Chunghun LimDepartment of Neurobiology, Northwestern University, Evanston, IL 60208.ORCID 0000-0001-8473-9272
Tae Hee HanDepartment of Neurobiology, Northwestern University, Evanston, IL 60208.ORCID 0000-0001-6223-9437
Tomas AndreaniDepartment of Neurobiology, Northwestern University, Evanston, IL 60208.
Matthew MoyeDepartment of Mathematical Sciences, New Jersey Institute of Technology, Newark, NJ 07102.ORCID 0000-0002-6546-2084
Jack CurranDepartment of Neurobiology, Northwestern University, Evanston, IL 60208.ORCID 0000-0003-2094-4095
Eric JohnsonDepartment of Engineering Sciences and Applied Math, Northwestern University, Evanston, IL 60208.
William L KathDepartment of Engineering Sciences and Applied Math, Northwestern University, Evanston, IL 60208.
Casey O DiekmanDepartment of Mathematical Sciences, New Jersey Institute of Technology, Newark, NJ 07102.ORCID 0000-0002-4711-1395
Bridget C LearDepartment of Neurobiology, Northwestern University, Evanston, IL 60208.ORCID 0000-0001-7741-5341
Ravi AlladaDepartment of Neurobiology, Northwestern University, Evanston, IL 60208; r-allada@northwestern.edu.
Northwestern University · USNew Jersey Institute of Technology · US

Funding

TRAINING GRANT IN SLEEP RESEARCHT32HL007909 · NHLBI · NORTHWESTERN UNIVERSITY · PI FRED W TUREK, Phyllis C. Zee · 1998 to 2026
$9.2M
Molecular Mechanisms Integrating Circadian Timing and Photic SignalingR01NS106955 · NINDS · NORTHWESTERN UNIVERSITY · PI ALLADA, RAVI · 2018 to 2022
$1.7M
The Function of a Novel Conserved Ion Channel in Daily BehaviorR56NS052903 · NINDS · NORTHWESTERN UNIVERSITY · PI ALLADA, RAVI · 2011 to 2011
$381k
NHLBI NIH HHS T32 HL007909NINDS NIH HHS R01 NS106955NINDS NIH HHS R56 NS052903
6 · The paper itself

Abstract

Circadian transcriptional timekeepers in pacemaker neurons drive profound daily rhythms in sleep and wake. Here we reveal a molecular pathway that links core transcriptional oscillators to neuronal and behavioral rhythms. Using two independent genetic screens, we identified mutants of

Indexed as

AnimalsAryl Hydrocarbon Receptor Nuclear TranslocatorCircadian ClocksCullin ProteinsDrosophilaDrosophila ProteinsNeuronsNeuropeptidesProteomicsSleepUbiquitin-Protein LigasesAryl Hydrocarbon Receptor Nuclear TranslocatorCul3 protein, DrosophilaCullin ProteinsDrosophila ProteinsNeuropeptidespdf protein, Drosophilatgo protein, DrosophilaUbiquitin-Protein Ligasescircadian rhythmsDrosophilaneuronal outputpotassium currentubiquitin ligase

Identifiers

PMID34799448
PMCPMC8617488
OpenAlexW3214653486

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.