ArticleProceedings of the National Academy of Sciences of the United States of America2021
Energetic scaling in microbial growth.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Thermodynamic dissipation constrains metabolic versatility of unicellular growth.Nature communications · 2025Article
- A framework for integrating genomics, microbial traits, and ecosystem biogeochemistry.Nature communications · 2025Article
- A powerful but frequently overlooked role of thermodynamics in environmental microbiology: inspirations from anammox.Applied and environmental microbiology · 2025Review
- The biogeography of soil microbiome potential growth rates.Nature communications · 2024Article
- Bioenergetic characterization of hyperthermophilic archaean Methanocaldococcus sp. FS406-22.Extremophiles : life under extreme conditions · 2024Article
- A self-regulated network for dynamically balancing multiple precursors in complex biosynthetic pathways.Metabolic engineering · 2024Article
- Predictions of rhizosphere microbiome dynamics with a genome-informed and trait-based energy budget model.Nature microbiology · 2024Article
- Ammonia Production Using Bacteria and Yeast toward a Sustainable Society.Bioengineering (Basel, Switzerland) · 2023Review
- Bioenergetics of aerobic and anaerobic growth ofFrontiers in microbiology · 2023Article
- Network representation and analysis of energy coupling mechanisms in cellular metabolism by a graph-theoretical approach.Theory in biosciences = Theorie in den Biowissenschaften · 2022Article
- Interacting Bioenergetic and Stoichiometric Controls on Microbial Growth.Frontiers in microbiology · 2022Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Microbial growth is a clear example of organization and structure arising in nonequilibrium conditions. Due to the complexity of the microbial metabolic network, elucidating the fundamental principles governing microbial growth remains a challenge. Here, we present a systematic analysis of microbial growth thermodynamics, leveraging an extensive dataset on energy-limited monoculture growth. A consistent thermodynamic framework based on reaction stoichiometry allows us to quantify how much of the available energy microbes can efficiently convert into new biomass while dissipating the remaining energy into the environment and producing entropy. We show that dissipation mechanisms can be linked to the electron donor uptake rate, a fact leading to the central result that the thermodynamic efficiency is related to the electron donor uptake rate by the scaling law [Formula: see text] and to the growth yield by [Formula: see text] These findings allow us to rederive the Pirt equation from a thermodynamic perspective, providing a means to compute its coefficients, as well as a deeper understanding of the relationship between growth rate and yield. Our results provide rather general insights into the relation between mass and energy conversion in microbial growth with potentially wide application, especially in ecology and biotechnology.
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