ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2022
Predictive Representations in Hippocampal and Prefrontal Hierarchies.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 49 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
49 citing papers in PubMed.
- Retrospective Grid Cells in the Medial Entorhinal Cortex Encode Past Paths During Spatial Navigation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Acetylcholine: a candidate substrate for hippocampal predictive learning?Nature reviews. Neuroscience · 2026Review
- Dorsomedial prefrontal cortex links abstract planning to motor execution.Communications biology · 2026Article
- Entorhinal Cortex Signals Dimensions of Past Experience That Can Be Generalized in a Novel Environment.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Top-down perceptual inference shaping the activity of early visual cortex.Nature communications · 2025Article
- A brain-inspired agentic architecture to improve planning with LLMs.Nature communications · 2025Article
- Cognitive maps for hierarchical spaces in the human brain.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- Replay in the human visual cortex during brief task pauses is linked to implicit learning of successor representations.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Multi-timescale reinforcement learning in the brain.Nature · 2025Article
- Empowering safer socially sensitive autonomous vehicles using human-plausible cognitive encoding.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Agency Modulation of Hippocampal Activity During Spatial Navigation.Research square · 2025Article
- Schemas, reinforcement learning and the medial prefrontal cortex.Nature reviews. Neuroscience · 2025Review
- Targeting Metabolic Dysregulation in Alzheimer's Disease: A Potential Therapeutic Strategy.Current drug metabolism · 2025Review
- A framework for uniting space and time in the mind and brain.Frontiers in cognition · 2025Article
- Causal and Chronological Relationships Predict Memory Organization for Nonlinear Narratives.Journal of cognitive neuroscience · 2024Article
- The brain hierarchically represents the past and future during multistep anticipation.Nature communications · 2024Article
- Consolidation Enhances Sequential Multistep Anticipation but Diminishes Access to Perceptual Features.Psychological science · 2024Article
- The brain hierarchically represents the past and future during multistep anticipation.bioRxiv : the preprint server for biology · 2024Article
- Reactivation strength during cued recall is modulated by graph distance within cognitive maps.eLife · 2024Article
- Local prediction-learning in high-dimensional spaces enables neural networks to plan.Nature communications · 2024Article
Corrections and comments
- Erratum issued
Authors and funding
2 authors.
Funding
Abstract
As we navigate the world, we use learned representations of relational structures to explore and to reach goals. Studies of how relational knowledge enables inference and planning are typically conducted in controlled small-scale settings. It remains unclear, however, how people use stored knowledge in continuously unfolding navigation (e.g., walking long distances in a city). We hypothesized that multiscale predictive representations guide naturalistic navigation in humans, and these scales are organized along posterior-anterior prefrontal and hippocampal hierarchies. We conducted model-based representational similarity analyses of neuroimaging data collected while male and female participants navigated realistically long paths in virtual reality. We tested the pattern similarity of each point, along each path, to a weighted sum of its successor points within predictive horizons of different scales. We found that anterior PFC showed the largest predictive horizons, posterior hippocampus the smallest, with the anterior hippocampus and orbitofrontal regions in between. Our findings offer novel insights into how cognitive maps support hierarchical planning at multiple scales.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.