Evidence map›Paper›PMID 34799100›Full record

ArticleAtherosclerosis2022

Associations of lower-limb atherosclerosis and arteriosclerosis with cardiovascular risk factors and disease in older adults: The Atherosclerosis Risk in Communities (ARIC) study.

Keeron Stone, Simon Fryer, James Faulkner, Michelle L Meyer, Kevin Heffernan, Anna Kucharska-Newton, Gabriel Zieff, Craig Paterson, Kunihiro Matsushita, Timothy M Hughes and 2 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Atherosclerosis, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
7.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 7 institutions in 3 countries.

Keeron StoneSchool of Sport and Exercise, University of Gloucestershire, Gloucester, UK. Electronic address: kstone1@glos.ac.uk.
Simon FryerSchool of Sport and Exercise, University of Gloucestershire, Gloucester, UK.
James FaulknerDepartment of Sport, Exercise & Health, University of Winchester, Winchester, UK.
Michelle L MeyerDepartment of Emergency Medicine, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Kevin HeffernanDepartment of Exercise Science, Syracuse University, Syracuse, USA.
Anna Kucharska-NewtonDepartment of Epidemiology, The Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Department of Epidemiology, College of Public Health, University of Kentucky, Lexington, KY, USA.
Gabriel ZieffDepartment of Exercise and Sport Science, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Craig PatersonSchool of Sport and Exercise, University of Gloucestershire, Gloucester, UK.
Kunihiro MatsushitaDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Timothy M HughesSection of Gerontology and Geriatric Medicine, Department of Internal Medicine, Wake Forest School of Medicine, Winston Salem, NC, USA.
Hirofumi TanakaDepartment of Kinesiology and Health Education, The University of Texas at Austin, Austin, TX, USA.
Lee StonerDepartment of Exercise and Sport Science, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
University of North Carolina at Chapel Hill · USUniversity of Gloucestershire · GBJohns Hopkins University · USSyracuse University · USThe University of Texas at Austin · USUniversity of Winchester · GBWake Forest University · US

Funding

Changes in arterial stiffness, cognition and dementia risk in a diverse cohortR01AG053938 · NIA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MEYER, MICHELLE · 2016 to 2020
$2.9M
NHLBI NIH HHS HHSN268201700001CNHLBI NIH HHS HHSN268201700001INHLBI NIH HHS HHSN268201700002CNHLBI NIH HHS HHSN268201700002INHLBI NIH HHS HHSN268201700003CNHLBI NIH HHS HHSN268201700003INHLBI NIH HHS HHSN268201700004CNHLBI NIH HHS HHSN268201700004INHLBI NIH HHS HHSN268201700005CNHLBI NIH HHS HHSN268201700005INIA NIH HHS R01 AG053938
6 · The paper itself

Abstract

BACKGROUND &

aimsAtherosclerosis and arteriosclerosis contribute to vascular aging and cardiovascular disease (CVD) risk. Both processes can be assessed simply in the lower-limbs and reflect systemic pathology. However, only atherosclerosis is routinely assessed, typically via ankle-brachial index (ABI). Arteriosclerosis can be assessed using femoral-ankle pulse wave velocity (faPWV), but no studies have identified whether ABI and faPWV similarly associate with overt CVD and risk factors, nor whether faPWV confers additional information. The aims of this study were to (i) compare associations of ABI and faPWV with traditional CVD risk factors, including age, sex, systolic blood pressure (SBP), high-density lipoprotein (HDL), total cholesterol (TC), smoking, and diabetes; and (ii) determine the independent and additive associations of ABI and faPWV with a composite measure of prevalent CVD.

methodsWe evaluated ABI and faPWV in 4330 older-aged (75.3 ± 5.0 years) adults using an oscillometric screening device. Associations between ABI and faPWV with CVD risk factors and CVD were determined using mixed-model linear- and logistic-regression.

resultsABI and faPWV were associated with age, HDL, and smoking. ABI was associated with sex, TC, diabetes. faPWV was associated with SBP. Both ABI and faPWV were inversely associated with CVD. Low ABI (≤0.9 vs. >0.9) and low faPWV (≤9.94 vs. >9.94) increased the odds of CVD by 2.41-fold (95% CI:1.85,3.17) and 1.46-fold (95% CI:1.23,1.74), respectively. The inverse association between faPWV and CVD was independent of ABI and CVD risk factors.

conclusionsABI and faPWV, measures of lower-limb atherosclerosis and arteriosclerosis, are independently associated with CVD risk factors and prevalent CVD. Assessment of faPWV may confer additional risk information beyond ABI.

Indexed as

AtherosclerosisCardiovascular DiseasesAgedAnkle Brachial IndexHeart Disease Risk FactorsHumansPulse Wave AnalysisRisk FactorsAnkle-brachial indexArterial stiffnessCardiovascular risk factorsCoronary heart diseaseFemoral-ankle pulse wave velocityHeart failurePeripheral artery diseaseStroke

Identifiers

PMID34799100
PMCPMC10167791
OpenAlexW3208771227

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.