Evidence map›Paper›PMID 34798958›Full record

ReviewRheumatic diseases clinics of North America2022

Systemic Autoinflammatory Diseases: A Growing Family of Disorders of Overlapping Immune Dysfunction.

Maria J Gutierrez, Sivia K Lapidus

Open access · greenAbstract readReview
In one paragraph

Review in Rheumatic diseases clinics of North America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Systemic autoinflammatory disorders.Clinical and experimental pediatrics · 2023
    Article
  5. Inflammation: A New Look at an Old Problem.International journal of molecular sciences · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Maria J GutierrezDivision of Pediatric Allergy, Immunology and Rheumatology, Johns Hopkins University School of Medicine, 600 North Wolfe Street CMSC 1102, Baltimore, MD 21287, USA.
Sivia K LapidusDivision of Pediatric Rheumatology, Joseph M. Sanzari Children's Hospital, Hackensack University Medical Center and Hackensack Meridian School of Medicine, 3WFAN 30 Prospect Avenue, Hackensack, NJ 07601, USA. Electronic address: sivia.lapidus@hmhn.org.
Hackensack University Medical Center · USJohns Hopkins University · US

Funding

“Role of Maternal Obesity in Epigenetic and Metabolic Programming and Lower Respiratory Infection Risk in Early Life” K23HD104933 · NICHD · JOHNS HOPKINS UNIVERSITY · PI GUTIERREZ, MARIA JIMENA · 2021 to 2025
$854k
NICHD NIH HHS K23 HD104933
6 · The paper itself

Abstract

Systemic autoinflammatory diseases (SAIDs) are characterized by unprovoked exaggerated inflammation on a continuum from benign recurrent oral ulceration to life-threatening strokes or amyloidosis, with renal failure as a potential sequela. The ability to discriminate these diagnoses rests on the genetic and mechanistic defect of each disorder, considering potential overlapping autoinflammation, autoimmunity, and immune deficiency. A comprehensive and strategic genetic investigation influences management as well as the consequential expected prognoses in these subsets of rare diseases. The ever-expanding therapeutic armamentarium reflects international collaborations, which will hasten genetic discovery and consensus-driven treatment.

Indexed as

Hereditary Autoinflammatory DiseasesAutoimmunityHumansInflammationAutoinflammatory diseaseImmune dysfunctionImmune dysregulationInborn errors of immunityPeriodic feversSystemic autoinflammatory disease

Identifiers

PMID34798958
PMCPMC9754298
OpenAlexW3213515331

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.