Evidence map›Paper›PMID 34798653›Full record

ArticleOphthalmic plastic and reconstructive surgery

Genome Sequencing and Apoptotic Markers to Assess Treatment Response of Lacrimal Gland Adenoid Cystic Carcinoma to Intra-Arterial Cytoreductive Chemotherapy.

Michael D Yu, Clara J Men, Huy Do, A Dimitrios Colevas, Jonathan H Lin, Peter R Egbert, David T Tse, Andrea L Kossler

Open access · greenAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Ophthalmic plastic and reconstructive surgery. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Michael D YuDepartment of Ophthalmology, Byers Eye Institute, Stanford University, Palo Alto, California, U.S.A.
Clara J MenDepartment of Ophthalmology, Byers Eye Institute, Stanford University, Palo Alto, California, U.S.A.
Huy DoDepartment of Interventional Neuroradiology, Stanford University, Stanford, California, U.S.A.
A Dimitrios ColevasDepartment of Medicine (Oncology), Stanford University, Stanford, California, U.S.A.
Jonathan H LinDepartment of Ophthalmology, Byers Eye Institute, Stanford University, Palo Alto, California, U.S.A.
Peter R EgbertDepartment of Ophthalmology, Byers Eye Institute, Stanford University, Palo Alto, California, U.S.A.
David T TseDepartment of Ophthalmology, Bascom Palmer Eye Institute, Miami, Florida, U.S.A.
Andrea L KosslerDepartment of Ophthalmology, Byers Eye Institute, Stanford University, Palo Alto, California, U.S.A.
Stanford University · US

Funding

Stanford Vision Research CoreP30EY026877 · NEI · STANFORD UNIVERSITY · PI Jeffrey L Goldberg · 2017 to 2026
$8.0M
NEI NIH HHS P30 EY026877
6 · The paper itself

Abstract

Adenoid cystic carcinoma of the lacrimal gland is an aggressive, malignant epithelial neoplasm. We report the case of a 30-year-old male with lacrimal gland adenoid cystic carcinoma treated with neoadjuvant intra-arterial chemotherapy through the internal carotid artery, followed by orbital exenteration and chemoradiation. Treatment response was evaluated using a novel combination of pre- and posttreatment genome sequencing coupled with immunohistochemical evaluation, which showed diffuse tumor apoptosis. A posttreatment decrease in variant allele frequency of the NOTCH1 mutation, and robust tumor cytoreduction on imaging, supports exploration of NOTCH1 analysis as a potential marker of cisplatin sensitivity. The use of genome sequencing and immunohistochemical evaluation could provide a more targeted therapeutic assessment of neoadjuvant intra-arterial chemotherapy in the management of lacrimal gland adenoid cystic carcinoma.

Indexed as

Carcinoma, Adenoid CysticEye NeoplasmsLacrimal ApparatusLacrimal Apparatus DiseasesAdultCytoreduction Surgical ProceduresHumansMale

Identifiers

PMID34798653
PMCPMC10838401
OpenAlexW3213434908

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.