Evidence map›Paper›PMID 34798503›Full record

ArticleJournal of photochemistry and photobiology. B, Biology2022

Ultraviolet-A light increases mitochondrial anti-viral signaling protein in confluent human tracheal cells via cell-cell signaling.

Gabriela Leite, Ali Rezaie, Ruchi Mathur, Gillian M Barlow, Gil Y Melmed, Mark Pimentel

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of photochemistry and photobiology. B, Biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Gabriela LeiteMedically Associated Science and Technology (MAST) Program, Cedars-Sinai, Los Angeles, CA, USA.
Ali RezaieMedically Associated Science and Technology (MAST) Program, Cedars-Sinai, Los Angeles, CA, USA; Karsh Division of Gastroenterology and Hepatology, Cedars-Sinai, Los Angeles, CA, USA.
Ruchi MathurMedically Associated Science and Technology (MAST) Program, Cedars-Sinai, Los Angeles, CA, USA; Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Cedars-Sinai, Los Angeles, CA, USA.
Gillian M BarlowMedically Associated Science and Technology (MAST) Program, Cedars-Sinai, Los Angeles, CA, USA.
Gil Y MelmedKarsh Division of Gastroenterology and Hepatology, Cedars-Sinai, Los Angeles, CA, USA.
Mark PimentelMedically Associated Science and Technology (MAST) Program, Cedars-Sinai, Los Angeles, CA, USA; Karsh Division of Gastroenterology and Hepatology, Cedars-Sinai, Los Angeles, CA, USA. Electronic address: mark.pimentel@cshs.org.
Cedars-Sinai Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mitochondrial antiviral signaling (MAVS) protein mediates innate antiviral responses, including responses to certain coronaviruses such as severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). We have previously shown that ultraviolet-A (UVA) therapy can prevent virus-induced cell death in human ciliated tracheal epithelial cells (HTEpC) infected with coronavirus-229E (CoV-229E), and results in increased intracellular levels of MAVS. In this study, we explored the mechanisms by which UVA light can activate MAVS, and whether local UVA light application can activate MAVS at locations distant from the light source (e.g. via cell-to-cell communication). MAVS levels were compared in HTEpC exposed to 2 mW/cm

Indexed as

Ultraviolet RaysAdaptor Proteins, Signal TransducingCell CommunicationCells, CulturedCOVID-19Epithelial CellsHost Microbial InteractionsHumansImmunity, InnatePhotobiologySARS-CoV-2Signal TransductionTracheaUltraviolet TherapyAdaptor Proteins, Signal TransducingMAVS protein, humanCell-cell signalingMitochondrial antiviral signaling (MAVS) proteinUltraviolet-A light

Identifiers

PMID34798503
PMCPMC8590474
OpenAlexW3213183219

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.