Evidence map›Paper›PMID 34798470›Full record

ArticleBiomedicine & pharmacotherapy = Biomedecine & pharmacotherapie2022

Inositol 1,4,5-trisphosphate receptor type 3 (ITPR3) is overexpressed in cholangiocarcinoma and its expression correlates with S100 calcium-binding protein A4 (S100A4).

Michele A Rodrigues, Dawidson A Gomes, Ana Luiza Cosme, Marcelo Dias Sanches, Vivian Resende, Geovanni D Cassali

Open access · goldAbstract read
In one paragraph

Article in Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Contrast media & molecular imaging · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Michele A RodriguesDepartment of General Pathology, Universidade Federal de Minas Gerais, Av. Antônio Carlos 6627, Belo Horizonte, Minas Gerais CEP 31270-901, Brazil.
Dawidson A GomesDepartment of Biochemistry and Immunology, Universidade Federal de Minas Gerais, Av. Antônio Carlos 6627, Belo Horizonte, Minas Gerais CEP 31270-901, Brazil.
Ana Luiza CosmeSchool of Medicine, Department of Surgery, Universidade Federal de Minas Gerais, Av. Prof. Alfredo Balena 190, Belo Horizonte, Minas Gerais CEP 30130-100, Brazil.
Marcelo Dias SanchesSchool of Medicine, Department of Surgery, Universidade Federal de Minas Gerais, Av. Prof. Alfredo Balena 190, Belo Horizonte, Minas Gerais CEP 30130-100, Brazil; Hepatopancreatobiliary Division, Clinical Hospital, Universidade Federal de Minas Gerais, Av. Prof. Alfredo Balena 110, Belo Horizonte, Minas Gerais CEP 30130-100, Brazil.
Vivian ResendeSchool of Medicine, Department of Surgery, Universidade Federal de Minas Gerais, Av. Prof. Alfredo Balena 190, Belo Horizonte, Minas Gerais CEP 30130-100, Brazil; Hepatopancreatobiliary Division, Clinical Hospital, Universidade Federal de Minas Gerais, Av. Prof. Alfredo Balena 110, Belo Horizonte, Minas Gerais CEP 30130-100, Brazil.
Geovanni D CassaliDepartment of General Pathology, Universidade Federal de Minas Gerais, Av. Antônio Carlos 6627, Belo Horizonte, Minas Gerais CEP 31270-901, Brazil. Electronic address: cassalig@icb.ufmg.br.
Universidade Federal de Minas Gerais · BR

Funding

Trafficking of the EGF receptor to the nucleus: Mechanisms and EffectsR03TW008709 · FIC · YALE UNIVERSITY · PI NATHANSON, MICHAEL H · 2012 to 2014
$230k
FIC NIH HHS R03 TW008709
6 · The paper itself

Abstract

Cholangiocarcinoma (CCA) is the second most malignant neoplasm in the liver that arises from the biliary tree. CCA is associated with a poor prognosis, and the key players involved in its pathogenesis are still not well understood. Receptor tyrosine kinases (RTKs), such as epidermal growth factor receptor (EGFR), can mediate intracellular calcium (Ca

Indexed as

Bile Duct NeoplasmsCalcium SignalingCholangiocarcinomaDisease ProgressionErbB ReceptorsFemaleGene Expression Regulation, NeoplasticHumansInositol 1,4,5-Trisphosphate ReceptorsLymphatic MetastasisMaleMiddle AgedNeoplasm StagingProteomicsS100 Calcium-Binding Protein A4Survival RateEGFR protein, humanErbB ReceptorsInositol 1,4,5-Trisphosphate ReceptorsITPR3 protein, humanS100A4 protein, humanS100 Calcium-Binding Protein A4CancerCholangiocarcinomaITPR3ITPRsLiverS100A4

Identifiers

PMID34798470
PMCPMC8678364
OpenAlexW3213277299

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.