ArticleCancer epidemiology2022
Sleep problems and risk of cancer incidence and mortality in an older cohort: The Cardiovascular Health Study (CHS).
Article in Cancer epidemiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.
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Who cites it
12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 25 citations in OpenAlex.
- The association between sleep quantity, insomnia and lung cancer risk - A systematic review and meta-analysis.Sleep & breathing = Schlaf & Atmung · 2024Pooled it
- Pooled it
- Impact of Sleep Health Domains on Chronic Conditions: Findings from a Cross-Sectional Analysis Using Data from the NHANES 2017-2020.Sleep science (Sao Paulo, Brazil) · 2026Article
- Exploring the genetic overlap between obstructive sleep apnea and prostate cancer.Journal of the National Cancer Center · 2026Article
- The Association of Sleep Trouble and Physical Inactivity with Breast Cancer Risk in Nova Scotia: Evidence from the Atlantic PATH Cohort.International journal of environmental research and public health · 2025Article
- Sleep and cancer mortality in the Cancer Prevention Study-II.Cancer causes & control : CCC · 2024Article
- Risk of cancer in patients with sleep apnea: comparison of surgery versus CPAP in a long-term follow-up study.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2024Article
- A cross-sectional analysis of the association between sleep disorders and cancer using data from the National Health and Nutrition Examination Survey (NHANES) 2005-2014.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2024Article
- Association between sleep problems and functional disability in community-dwelling older adults.BMC geriatrics · 2024Article
- Actigraphy-derived measures of sleep and risk of prostate cancer in the UK Biobank.Journal of the National Cancer Institute · 2024Article
- Sex-specific associations between habitual snoring and cancer prevalence: insights from a US Cohort Study.Sleep advances : a journal of the Sleep Research Society · 2024Article
- Incidence disparities of obstructive sleep apnea-associated lung cancer by gender; Korean National Health Insurance data analysis.Frontiers in oncology · 2023Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundSleep problems (SP) can indicate underlying sleep disorders, such as obstructive sleep apnea, which may adversely impact cancer risk and mortality.
methodsWe assessed the association of baseline and longitudinal sleep apnea and insomnia symptoms with incident cancer (N = 3930) and cancer mortality (N = 4580) in the Cardiovascular Health Study. We used Cox proportional hazards regression to calculate adjusted hazard ratios (HR) and 95% confidence intervals (CI) to evaluate the associations.
resultsOverall, 885 incident cancers and 804 cancer deaths were identified over a median follow-up of 12 and 14 years, respectively. Compared to participants who reported no sleep apnea symptoms, the risk of incident cancer was inversely associated [(HR (95%CI)] with snoring [0.84 (0.71, 0.99)]. We noted an elevated prostate cancer incidence for apnea [2.34 (1.32, 4.15)] and snoring [1.69 (1.11, 2.57)]. We also noted an elevated HR for lymphatic or hematopoietic cancers [daytime sleepiness: 1.81 (1.06, 3.08)]. We found an inverse relationship for cancer mortality with respect to snoring [0.73 (0.62, 0.8)] and apnea [(0.69 (0.51, 0.94))]. We noted a significant inverse relationship between difficulty falling asleep and colorectal cancer death [0.32 (0.15, 0.69)] and snoring with lung cancer death [0.56 (0.35, 0.89)].
conclusionsThe relationship between SP and cancer risk and mortality was heterogeneous. Larger prospective studies addressing more cancer sites, molecular type-specific associations, and better longitudinal SP assessments are needed for improved delineation of SP-cancer risk dyad.
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