ArticleThe ocular surface2022
Spontaneous acinar and ductal regrowth after meibomian gland atrophy induced by deletion of FGFR2 in a mouse model.
Article in The ocular surface, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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Who cites it
10 citing papers in PubMed, 17 citations in OpenAlex.
- Anteroplacement of the Mucocutaneous Junction and Goblet Cell Expansion: Microanatomic Remodeling of the Human Eyelid Margin.Investigative ophthalmology & visual science · 2026Article
- Ferroptosis in Meibomian Gland Progenitor Cells Contributes to Pathogenesis of Meibomian Gland Dysfunction.Investigative ophthalmology & visual science · 2026Article
- Corneal subbasal nerve alterations and tear cytokine associations in ocular chronic graft-versus-host disease.Frontiers in medicine · 2025Article
- Deletion of Fgfr2 in Ductal Basal Epithelium With Tamoxifen Induces Obstructive Meibomian Gland Dysfunction.Investigative ophthalmology & visual science · 2024Article
- Isolation and Culture of Human Meibomian Gland Ductal Cells.Investigative ophthalmology & visual science · 2023Article
- Recent advances in age-related meibomian gland dysfunction (ARMGD).The ocular surface · 2023Review
- Distinct mechanisms for sebaceous gland self-renewal and regeneration provide durability in response to injury.Cell reports · 2023Article
- Meibomian gland stem/progenitor cells: The hunt for gland renewal.The ocular surface · 2023Article
- Distinct mechanisms for sebaceous gland self-renewal and regeneration provide durability in response to injury.bioRxiv : the preprint server for biology · 2023Article
- Ductal Hyperkeratinization and Acinar Renewal Abnormality: New Concepts on Pathogenesis of Meibomian Gland Dysfunction.Current issues in molecular biology · 2023Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
purposeWe have demonstrated that deletion of fibroblast growth factor receptor 2 gene (Fgfr2) leads to Meibomian gland (MG) atrophy in an inducible conditional knockout mouse model, referred as Fgfr2
methodsTwo months old Fgfr2
resultsSingle Dox injection in Fgfr2
conclusionsOur current findings further substantiate the role of FGFR2 in MG homeostasis, and suggest that FGFR2-signaling may provide a potential strategy for regenerating acini from age-related MG dysfunction in humans. Our data demonstrated that spontaneous MG recovery depends on the extent of ductal atrophy, suggesting that ductal epithelia may provide the progenitor cells for acinar regeneration. Nonetheless, the role of ductal tissue as the source of acinar progenitors awaits further investigation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.