Evidence map›Paper›PMID 34798138›Full record

ArticleBiophysical journal2021

The impact of the glycan headgroup on the nanoscopic segregation of gangliosides.

Maria J Sarmento, Michael C Owen, Joana C Ricardo, Barbora Chmelová, David Davidović, Ilya Mikhalyov, Natalia Gretskaya, Martin Hof, Mariana Amaro, Robert Vácha and 1 more

Open access · greenAbstract read
In one paragraph

Article in Biophysical journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
  2. Single-Photon Single-Particle Tracking.bioRxiv : the preprint server for biology · 2025
    Article
  3. Article
  4. Unraveling the GMACS bio & med chem Au · 2025
    Article
  5. Article
  6. Article
  7. Article
  8. Which Moiety Drives Gangliosides to Form Nanodomains?The journal of physical chemistry letters · 2023
    Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 3 countries.

Maria J SarmentoJ. Heyrovský Institute of Physical Chemistry of the Czech Academy of Sciences, Prague, Czech Republic.
Michael C OwenCEITEC - Central European Institute of Technology, Masaryk University, Brno, Czech Republic; Institute of Chemistry, Faculty of Materials Science and Engineering, University of Miskolc, 3515 Miskolc, Hungary.
Joana C RicardoJ. Heyrovský Institute of Physical Chemistry of the Czech Academy of Sciences, Prague, Czech Republic.
Barbora ChmelováJ. Heyrovský Institute of Physical Chemistry of the Czech Academy of Sciences, Prague, Czech Republic; Faculty of Mathematics and Physics, Charles University, Prague, Czech Republic.
David DavidovićJ. Heyrovský Institute of Physical Chemistry of the Czech Academy of Sciences, Prague, Czech Republic.
Ilya MikhalyovShemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Science, Moscow Ul. Miklukho-Maklaya, Moscow 117997, Russia.
Natalia GretskayaShemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Science, Moscow Ul. Miklukho-Maklaya, Moscow 117997, Russia.
Martin HofJ. Heyrovský Institute of Physical Chemistry of the Czech Academy of Sciences, Prague, Czech Republic.
Mariana AmaroJ. Heyrovský Institute of Physical Chemistry of the Czech Academy of Sciences, Prague, Czech Republic.
Robert VáchaCEITEC - Central European Institute of Technology, Masaryk University, Brno, Czech Republic.
Radek ŠachlJ. Heyrovský Institute of Physical Chemistry of the Czech Academy of Sciences, Prague, Czech Republic. Electronic address: radek.sachl@jh-inst.cas.cz.
Czech Academy of Sciences, J. Heyrovský Institute of Physical Chemistry · CZCentral European Institute of Technology · CZInstitute of Bioorganic Chemistry · RUCharles University · CZ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gangliosides form an important class of receptor lipids containing a large oligosaccharide headgroup whose ability to self-organize within lipid membranes results in the formation of nanoscopic platforms. Despite their biological importance, the molecular basis for the nanoscopic segregation of gangliosides is not clear. In this work, we investigated the role of the ganglioside headgroup on the nanoscale organization of gangliosides. We studied the effect of the reduction in the number of sugar units of the ganglioside oligosaccharide chain on the ability of gangliosides GM

Indexed as

GangliosidesG(M1) GangliosideFluorescence Resonance Energy TransferMolecular Dynamics SimulationOligosaccharidesGangliosidesG(M1) GangliosideOligosaccharides

Identifiers

PMID34798138
PMCPMC8715245
OpenAlexW3214202452

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.