Evidence map›Paper›PMID 34798136›Full record

ArticleExperimental neurology2022

Spinal cord injury-mediated changes in electrophysiological properties of rat gastric nodose ganglion neurons.

Emily N Blanke, Victor Ruiz-Velasco, Gregory M Holmes

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Role of voltage-gated CaJournal of neurophysiology · 2025
    Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Emily N BlankeDepartment of Neural and Behavioral Sciences, Penn State College of Medicine, Hershey, PA, United States of America.
Victor Ruiz-VelascoDepartment of Anesthesiology and Perioperative Medicine, Penn State College of Medicine, Hershey, PA, United States of America.
Gregory M HolmesDepartment of Neural and Behavioral Sciences, Penn State College of Medicine, Hershey, PA, United States of America. Electronic address: gmh16@psu.edu.

Funding

Gastric dysreflexia after spinal cord injuryR01NS049177 · NINDS · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI HOLMES, GREGORY M. · 2006 to 2015
$3.1M
Pathophysiological remodeling of the enteric neuromuscular compartment in experimental spinal cord injuryR01NS105987 · NINDS · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI HOLMES, GREGORY M. · 2019 to 2023
$1.7M
NINDS NIH HHS R01 NS049177NINDS NIH HHS R01 NS105987
6 · The paper itself

Abstract

In preclinical rodent models, spinal cord injury (SCI) manifests as gastric vagal afferent dysfunction both acutely and chronically. However, the mechanism that underlies this dysfunction remains unknown. In the current study, we examined the effect of SCI on gastric nodose ganglia (NG) neuron excitability and on voltage-gated Na

Indexed as

Action PotentialsAnimalsMaleNAV1.8 Voltage-Gated Sodium ChannelNeuronsNodose GanglionRatsRats, WistarSpinal Cord InjuriesNAV1.8 Voltage-Gated Sodium ChannelScn10a protein, ratGastric neuronsNodose ganglion (NG) neuronsSpinal cord injury (SCI)Visceral afferent signalingVoltage-gated Na(+) channels (Na(V))Whole-cell patch-clamp

Identifiers

PMID34798136
PMCPMC8727501

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.