Evidence map›Paper›PMID 34798078›Full record

ArticleThe Journal of pediatrics2022

Mortality Risk Factors among Infants Receiving Dialysis in the Neonatal Intensive Care Unit.

Keia R Sanderson, Bradley Warady, William Carey, Veeral Tolia, Marcella H Boynton, Daniel K Benjamin, Wesley Jackson, Matthew Laughon, Reese H Clark, Rachel G Greenberg

Open access · greenAbstract read
In one paragraph

Article in The Journal of pediatrics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 14 citations in OpenAlex.

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  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 7 institutions in 1 country.

Keia R SandersonDivision of Nephrology and Hypertension, University of North Carolina, Chapel Hill, NC. Electronic address: keia_sanderson@med.unc.edu.
Bradley WaradyDivision of Pediatric Nephrology, Children's Mercy Kansas City, Kansas City, MO.
William CareyDivision of Neonatal Medicine, Mayo Clinic, Rochester, MN.
Veeral ToliaThe MEDNAX Center for Research, Education, Quality and Safety, Sunrise, FL; Division of Neonatology, Department of Pediatrics, Baylor University Medical Center, Dallas, TX.
Marcella H BoyntonDepartment of Medicine-Internal Medicine, University of North Carolina, Chapel Hill, NC; North Carolina Translational and Clinical Sciences Institute, Chapel Hill, NC.
Daniel K BenjaminDepartment of Economics, Clemson University, Clemson, SC.
Wesley JacksonDivision of Neonatology, Department of Pediatrics, University of North Carolina, Chapel Hill, NC.
Matthew LaughonDivision of Neonatology, Department of Pediatrics, University of North Carolina, Chapel Hill, NC.
Reese H ClarkThe MEDNAX Center for Research, Education, Quality and Safety, Sunrise, FL; Greenville Health System, Greenville, SC.
Rachel G GreenbergDivision of Neonatology, Department of Pediatrics, Duke University, Durham, NC; Duke Clinical Research Institute, Durham, NC.
University of North Carolina at Chapel Hill · USBaylor University Medical Center · USChildren's Mercy Hospital · USClemson University · USDuke University · USMayo Clinic in Arizona · USPrisma Health · US

Funding

North Carolina Translational and Clinical Science Institute (NC TraCS) KL2KL2TR002490 · NCATS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI WEINBERGER, MORRIS · 2018 to 2022
$11.0M
Mentorship of Early-Career Clinicians in Bronchopulmonary Dysplasia Drug TherapiesK24HL143283 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI LAUGHON, MATTHEW · 2019 to 2023
$613k
NCATS NIH HHS KL2 TR002490NHLBI NIH HHS K24 HL143283
6 · The paper itself

Abstract

objectivesTo identify risk factors associated with mortality for infants receiving dialysis in the neonatal intensive care unit (NICU). STUDY

designIn this retrospective cohort study, we extracted data from the Pediatrix Clinical Data Warehouse on all infants who received dialysis in the NICU from 1999 to 2018. Using a Cox proportional hazards model with robust SEs we estimated the mortality hazard ratios associated with demographics, birth details, medical complications, and treatment exposures.

resultsWe identified 273 infants who received dialysis. Median gestational age at birth was 35 weeks (interquartile values 33-37), median birth weight was 2570 g (2000-3084), 8% were small for gestational age, 41% white, and 72% male. Over one-half of the infants (59%) had a kidney anomaly; 71 (26%) infants died before NICU hospital discharge. Factors associated with increased risk of dying after dialysis initiation included lack of kidney anomalies, Black race, gestational age of <32 weeks, necrotizing enterocolitis, dialysis within 7 days of life, and receipt of paralytics or vasopressors (all P < .05).

conclusionIn this cohort of infants who received dialysis in the NICU over 2 decades, more than 70% of infants survived. The probability of death was greater among infants without a history of a kidney anomaly and those with risk factors consistent with greater severity of illness at dialysis initiation.

Indexed as

Infant, Newborn, DiseasesIntensive Care Units, NeonatalBirth WeightFemaleHumansInfantInfant MortalityInfant, NewbornMaleRenal DialysisRetrospective StudiesRisk Factorsacute kidney injurychronic kidney diseasecontinuous kidney replacement therapydialysisneonatalperitoneal dialysis

Identifiers

PMID34798078
PMCPMC8882152
OpenAlexW3212587525

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.