ArticleMolecular cell2021
Parp1 promotes sleep, which enhances DNA repair in neurons.
Article in Molecular cell, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
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Who cites it
51 citing papers in PubMed, 106 citations in OpenAlex.
- Invertebrate brains as diversified models for understanding sleep mechanisms and function.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2026Review
- Sleep Disorders in Neurodegenerative Diseases: Pathological Correlations and Underlying Mechanisms.Neuroscience bulletin · 2026Review
- Temporal drift of sleep-wake representations in hypothalamic neuronal ensembles.Nature communications · 2026Article
- NADAlzheimer's & dementia : the journal of the Alzheimer's Association · 2026Review
- Beyond RBD: covert REM sleep abnormalities in Parkinson's disease.NPJ Parkinson's disease · 2026Article
- DNA damage modulates sleep drive in basal cnidarians with divergent chronotypes.Nature communications · 2026Article
- Looking back: tracing the origins of sleep across the animal kingdom.Frontiers in neuroscience · 2026Review
- Contributions of Zebrafish to Our Understanding of the Function and Regulation of Sleep.Current sleep medicine reports · 2026Review
- Sleep and circadian regulation of DNA repair and retrotransposons in neuronal genome stability and neurodegenerative disease mechanisms.Frontiers in neuroscience · 2026Review
- Tatdn2 is required for DNA repair to safeguard genome stability in primordial germ cells.Nucleic acids research · 2025Article
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- Role of d-serine in intestinal ROS accumulation after sleep deprivation.Science advances · 2025Article
- Transcriptional dynamics of sleep deprivation and subsequent recovery sleep in the male mouse cortex.Physiological genomics · 2025Article
- ATR Deficiency Impairs DNA Damage Repair and Accelerates Cellular Senescence in Bovine Mammary Epithelial Cells, Leading to Lactation Dysfunction.Animals : an open access journal from MDPI · 2025Article
- Analyzing different aging theories in the context of the brain: DNA damage, inflammation, redox imbalance, and neurodevelopment intertwine.Biogerontology · 2025Review
- Effects of Cadmium and Lead Co-exposure on Sleep Status in Rural Areas Northwestern China.Biological trace element research · 2025Article
- Enhancement of physiology via adaptive transcription.Pflugers Archiv : European journal of physiology · 2025Review
- The hepatic clock synergizes with HIF-1α to regulate nucleotide availability during liver damage repair.Nature metabolism · 2025Article
- Unraveling the interplay between sleep, redox metabolism, and aging: implications for brain health and longevity.Frontiers in aging · 2025Review
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
The characteristics of the sleep drivers and the mechanisms through which sleep relieves the cellular homeostatic pressure are unclear. In flies, zebrafish, mice, and humans, DNA damage levels increase during wakefulness and decrease during sleep. Here, we show that 6 h of consolidated sleep is sufficient to reduce DNA damage in the zebrafish dorsal pallium. Induction of DNA damage by neuronal activity and mutagens triggered sleep and DNA repair. The activity of the DNA damage response (DDR) proteins Rad52 and Ku80 increased during sleep, and chromosome dynamics enhanced Rad52 activity. The activity of the DDR initiator poly(ADP-ribose) polymerase 1 (Parp1) increased following sleep deprivation. In both larva zebrafish and adult mice, Parp1 promoted sleep. Inhibition of Parp1 activity reduced sleep-dependent chromosome dynamics and repair. These results demonstrate that DNA damage is a homeostatic driver for sleep, and Parp1 pathways can sense this cellular pressure and facilitate sleep and repair activity.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.