Evidence map›Paper›PMID 34797987›Full record

ArticleACS sensors2021

Electrochemical Detection of Single-Nucleotide Polymorphism Associated with Rifampicin Resistance in

Mayreli Ortiz, Miriam Jauset-Rubio, Vasso Skouridou, Diana Machado, Miguel Viveiros, Taane G Clark, Anna Simonova, David Kodr, Michal Hocek, Ciara K O'Sullivan

Open access · hybridAbstract read
In one paragraph

Article in ACS sensors, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 20 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 4 countries.

Mayreli OrtizDepartament d'Enginyeria Química, Universitat Rovira i Virgili, Avinguda Països Catalans 26, 43007 Tarragona, Spain.ORCID 0000-0002-9423-0055
Miriam Jauset-RubioDepartament d'Enginyeria Química, Universitat Rovira i Virgili, Avinguda Països Catalans 26, 43007 Tarragona, Spain.
Vasso SkouridouDepartament d'Enginyeria Química, Universitat Rovira i Virgili, Avinguda Països Catalans 26, 43007 Tarragona, Spain.ORCID 0000-0002-9712-5429
Diana MachadoGlobal Health and Tropical Medicine, GHTM, Instituto de Higiene e Medicina Tropical, IHMT, Universidade Nova de Lisboa, Rua da Junqueira, 100, 1349-008 Lisbon, Portugal.
Miguel ViveirosGlobal Health and Tropical Medicine, GHTM, Instituto de Higiene e Medicina Tropical, IHMT, Universidade Nova de Lisboa, Rua da Junqueira, 100, 1349-008 Lisbon, Portugal.
Taane G ClarkGlobal Health and Tropical Medicine, GHTM, Instituto de Higiene e Medicina Tropical, IHMT, Universidade Nova de Lisboa, Rua da Junqueira, 100, 1349-008 Lisbon, Portugal.
Anna SimonovaInstitute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Flemingovo nam.2, 16610 Prague 6, Czech Republic.
David KodrInstitute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Flemingovo nam.2, 16610 Prague 6, Czech Republic.ORCID 0000-0002-5948-6426
Michal HocekInstitute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Flemingovo nam.2, 16610 Prague 6, Czech Republic.ORCID 0000-0002-1113-2047
Ciara K O'SullivanDepartament d'Enginyeria Química, Universitat Rovira i Virgili, Avinguda Països Catalans 26, 43007 Tarragona, Spain.ORCID 0000-0003-2603-2230
Universitat Rovira i Virgili · ESCharles University · CZUniversidade Nova de Lisboa · PTCzech Academy of Sciences, Institute of Organic Chemistry and Biochemistry · CZInstitució Catalana de Recerca i Estudis Avançats · ESUniversity of London · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Here, we report the electrochemical detection of single-point mutations using solid-phase isothermal primer elongation with redox-labeled oligonucleotides. A single-base mutation associated with resistance to rifampicin, an antibiotic commonly used for the treatment of

Indexed as

Mycobacterium tuberculosisMetallocenesOxidation-ReductionPolymorphism, Single NucleotideRifampinMetallocenesRifampinferrocene-labeled nucleotidesKlenow (exo-) DNA polymerasenucleoside triphosphatessingle-nucleotide polymorphism (SNP)single-point mutationsolid-phase primer elongation

Identifiers

PMID34797987
PMCPMC8715531
OpenAlexW3212761539

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.