ArticleAnalytical chemistry2021
High-Throughput Molecular Imaging via Deep-Learning-Enabled Raman Spectroscopy.
Article in Analytical chemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed.
- Development of scanning ion-conductance microscopy based tip-enhanced Raman spectroscopy in liquid environments.Nanotechnology · 2026Review
- Longitudinal Morphomolecular Monitoring of Head and Neck Carcinogenesis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Gaps between Laboratory Experiments and Real-World Exposure: Toxicological Assessment of Microplastics Is Based on Inadequate Evidence.Environment & health (Washington, D.C.) · 2026Review
- Photonic biosensors based on nanoparticle superstructures: from data analysis to artificial intelligence (AI) detection.Fundamental research · 2026Review
- Proof of Concept for a Controlled Raman-Compatible Skin-Mimicking Hydrogel Substrate for Chemical Imaging Technique Development.Molecules (Basel, Switzerland) · 2026Article
- Advanced Imaging for Live-Cell Spatiotemporal Monitoring: Technologies and Applications.Research (Washington, D.C.) · 2026Review
- Rapid hyperspectral Raman imaging of cells with depthwise separable 3D MultiResU-Net.iScience · 2025Article
- Review
- Artificial Intelligence-Powered Raman Spectroscopy through Open Science and FAIR Principles.ACS nano · 2025Review
- Open Raman Microscopy (ORM): A Modular Hardware and Software Framework for Accessible Raman Imaging.bioRxiv : the preprint server for biology · 2025Article
- Rapid Detection of Perfluorooctanesulfonic Acid Using Surface-Enhanced Raman Spectroscopy and Deep Learning.ACS omega · 2025Article
- CryoEMNet driven symmetry-aware molecular reconstruction through deep learning enhanced electron microscopy.Scientific reports · 2025Article
- Neural Network-Enhanced FMCW Gas Spectroscopy.ACS sensors · 2025Article
- Analysis of Chemical Heterogeneity in Electrospun Fibers Through Hyperspectral Raman Imaging Using Open-Source Software.Polymers · 2025Article
- SlitNET: A Deep Learning Enabled Spectrometer Slit.Analytical chemistry · 2025Article
- Interpretable Multiscale Convolutional Neural Network for Classification and Feature Visualization of Weak Raman Spectra of Biomolecules at Cell Membranes.ACS sensors · 2025Article
- Surface-Enhanced Raman Spectroscopy for Biomedical Applications: Recent Advances and Future Challenges.ACS applied materials & interfaces · 2025Review
- Adaptive Raman spectral unmixing method based on Voigt peak compensation for quantitative analysis of cellular biochemical components.Biomedical optics express · 2025Article
- Machine learning empowered coherent Raman imaging and analysis for biomedical applications.Communications engineering · 2025Review
- Improving signal-to-noise ratio of Raman measurements based on ensemble learning approach.Analytical and bioanalytical chemistry · 2025Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Raman spectroscopy enables nondestructive, label-free imaging with unprecedented molecular contrast, but is limited by slow data acquisition, largely preventing high-throughput imaging applications. Here, we present a comprehensive framework for higher-throughput molecular imaging via deep-learning-enabled Raman spectroscopy, termed DeepeR, trained on a large data set of hyperspectral Raman images, with over 1.5 million spectra (400 h of acquisition) in total. We first perform denoising and reconstruction of low signal-to-noise ratio Raman molecular signatures via deep learning, with a 10× improvement in the mean-squared error over common Raman filtering methods. Next, we develop a neural network for robust 2-4× spatial super-resolution of hyperspectral Raman images that preserve molecular cellular information. Combining these approaches, we achieve Raman imaging speed-ups of up to 40-90×, enabling good-quality cellular imaging with a high-resolution, high signal-to-noise ratio in under 1 min. We further demonstrate Raman imaging speed-up of 160×, useful for lower resolution imaging applications such as the rapid screening of large areas or for spectral pathology. Finally, transfer learning is applied to extend DeepeR from cell to tissue-scale imaging. DeepeR provides a foundation that will enable a host of higher-throughput Raman spectroscopy and molecular imaging applications across biomedicine.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.