Evidence map›Paper›PMID 34797719›Full record

ArticleScience advances2021

A wireless and battery-free wound infection sensor based on DNA hydrogel.

Ze Xiong, Sippanat Achavananthadith, Sophie Lian, Leigh Edward Madden, Zi Xin Ong, Wisely Chua, Viveka Kalidasan, Zhipeng Li, Zhu Liu, Priti Singh and 16 more

Abstract read
In one paragraph

Article in Science advances, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
56citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

56 citing papers in PubMed, 1 synthesis or guideline pooled it.

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  12. Advances in biosensors for bacterial detection and identification.World journal of microbiology & biotechnology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors.

Ze XiongDepartment of Electrical and Computer Engineering, National University of Singapore, Singapore 117583, Singapore.ORCID 0000-0003-4620-6066
Sippanat AchavananthadithDepartment of Electrical and Computer Engineering, National University of Singapore, Singapore 117583, Singapore.ORCID 0000-0002-2757-7235
Sophie LianDepartment of Biomedical Engineering, National University of Singapore, Singapore 117583, Singapore.ORCID 0000-0001-5393-7532
Leigh Edward MaddenLee Kong Chian School of Medicine, Nanyang Technological University, Singapore 308232, Singapore.ORCID 0000-0003-1111-9288
Zi Xin OngLee Kong Chian School of Medicine, Nanyang Technological University, Singapore 308232, Singapore.ORCID 0000-0001-8035-4666
Wisely ChuaInstitute of Molecular and Cell Biology, A*STAR, Singapore 138669, Singapore.
Viveka KalidasanDepartment of Electrical and Computer Engineering, National University of Singapore, Singapore 117583, Singapore.ORCID 0000-0001-6890-2527
Zhipeng LiDepartment of Electrical and Computer Engineering, National University of Singapore, Singapore 117583, Singapore.ORCID 0000-0002-8139-2522
Zhu LiuDepartment of Electrical and Computer Engineering, National University of Singapore, Singapore 117583, Singapore.ORCID 0000-0001-7047-9238
Priti SinghFaculty of Dentistry, National University of Singapore, Singapore 119085, Singapore.ORCID 0000-0002-9327-3125
Haitao YangDepartment of Chemical and Biomolecular Engineering, National University of Singapore, Singapore 117585, Singapore.ORCID 0000-0002-0375-0873
Sascha P HeusslerAttonics Systems Pte Ltd., Singapore 079903, Singapore.ORCID 0000-0002-5935-0094
S M P KalaiselviSingapore Synchrotron Light Source, National University of Singapore, Singapore 117603, Singapore.ORCID 0000-0002-0691-989X
Mark B H BreeseSingapore Synchrotron Light Source, National University of Singapore, Singapore 117603, Singapore.ORCID 0000-0003-1881-7257
Haicheng YaoDepartment of Materials Science and Engineering, National University of Singapore, Singapore 117575, Singapore.ORCID 0000-0003-0264-6203
Yuji GaoInstitute for Health Innovation and Technology, National University of Singapore, Singapore 117599, Singapore.ORCID 0000-0001-7222-647X
Kavitha SanmugamSt Luke's Hospital, Singapore 659674, Singapore.
Benjamin C K TeeDepartment of Electrical and Computer Engineering, National University of Singapore, Singapore 117583, Singapore.ORCID 0000-0002-9180-4105
Po-Yen ChenDepartment of Chemical and Biomolecular Engineering, National University of Singapore, Singapore 117585, Singapore.ORCID 0000-0003-0310-4748
Weiqiang LokeFaculty of Dentistry, National University of Singapore, Singapore 119085, Singapore.ORCID 0000-0002-1634-2932
Chwee Teck LimInstitute for Health Innovation and Technology, National University of Singapore, Singapore 117599, Singapore.ORCID 0000-0003-4019-9782
Grace Shu Hui ChiangSt Luke's Hospital, Singapore 659674, Singapore.
Boon Yeow TanSt Luke's Hospital, Singapore 659674, Singapore.
Hao LiNanyang Institute of Technology in Health and Medicine, Interdisciplinary Graduate Programme, Nanyang Technological University, Singapore 637335, Singapore.ORCID 0000-0002-6652-4793
David Laurence BeckerLee Kong Chian School of Medicine, Nanyang Technological University, Singapore 308232, Singapore.ORCID 0000-0002-9300-0899
John S HoDepartment of Electrical and Computer Engineering, National University of Singapore, Singapore 117583, Singapore.ORCID 0000-0002-9458-9033

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The confluence of wireless technology and biosensors offers the possibility to detect and manage medical conditions outside of clinical settings. Wound infections represent a major clinical challenge in which timely detection is critical for effective interventions, but this is currently hindered by the lack of a monitoring technology that can interface with wounds, detect pathogenic bacteria, and wirelessly transmit data. Here, we report a flexible, wireless, and battery-free sensor that provides smartphone-based detection of wound infection using a bacteria-responsive DNA hydrogel. The engineered DNA hydrogels respond selectively to deoxyribonucleases associated with pathogenic bacteria through tunable dielectric changes, which can be wirelessly detected using near-field communication. In a mouse acute wound model, we demonstrate that the wireless sensor can detect physiologically relevant amounts of

Identifiers

PMID34797719
PMCPMC8604401

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.