Evidence map›Paper›PMID 34797496›Full record

ReviewActa parasitologica2022

Potential Emergence of Plasmodium Resistance to Artemisinin Induced by the Use of Artemisia annua for Malaria and COVID-19 Prevention in Sub-African Region.

Essoham Ataba, Ameyo M Dorkenoo, Christèle Tchopba Nguepou, Tchaa Bakai, Tchassama Tchadjobo, Komla Dovenè Kadzahlo, Kossi Yakpa, Tinah Atcha-Oubou

Erratum issuedOpen access · bronzeAbstract readReview
In one paragraph

Review in Acta parasitologica, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 21 citations in OpenAlex.

  1. Public Health Perspectives on IntegratingTropical medicine and infectious disease · 2026
    Article
  2. Medicinal plants as more sustainable therapeutic solutions:Global health economics and sustainability · 2025
    Article
  3. Review
  4. Article
  5. Artemisinin as a therapeuticNatural product reports · 2023
    Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Essoham AtabaEcole Supérieure des Techniques Biologiques et Alimentaires (ESTBA) /Unité de Recherche en Immunologie et Immunomodulation (UR2IM), Université de Lomé, Boulevard Eyadema, 01BP 1515, Lomé, Togo. fidelcab10@gmail.com.ORCID http://orcid.org/0000-0002-0233-5619
Ameyo M DorkenooFaculté des Sciences de la Santé, Université de Lomé, Boulevard Eyadema, 01BP 1515, Lomé, Togo.
Christèle Tchopba NguepouEcole Supérieure des Techniques Biologiques et Alimentaires (ESTBA) /Unité de Recherche en Immunologie et Immunomodulation (UR2IM), Université de Lomé, Boulevard Eyadema, 01BP 1515, Lomé, Togo.
Tchaa BakaiProgramme National de Lutte Contre le Paludisme, Ministère de la Santé de l'Hygiène Publique et de l'Accès Universel Aux Soins, Quartier Administratif, 01BP 518, Lomé, Togo.
Tchassama TchadjoboProgramme National de Lutte Contre le Paludisme, Ministère de la Santé de l'Hygiène Publique et de l'Accès Universel Aux Soins, Quartier Administratif, 01BP 518, Lomé, Togo.
Komla Dovenè KadzahloProgramme National de Lutte Contre le Paludisme, Ministère de la Santé de l'Hygiène Publique et de l'Accès Universel Aux Soins, Quartier Administratif, 01BP 518, Lomé, Togo.
Kossi YakpaProgramme National de Lutte Contre le Paludisme, Ministère de la Santé de l'Hygiène Publique et de l'Accès Universel Aux Soins, Quartier Administratif, 01BP 518, Lomé, Togo.
Tinah Atcha-OubouProgramme National de Lutte Contre le Paludisme, Ministère de la Santé de l'Hygiène Publique et de l'Accès Universel Aux Soins, Quartier Administratif, 01BP 518, Lomé, Togo.
University of Lomé · TGMinistère de la Santé et de l'Hygiène Publique · ML

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Plasmodium resistance to antimalarial drugs is an obstacle to the elimination of malaria in endemic areas. This situation is particularly dramatic for Africa, which accounts for nearly 92% of malaria cases worldwide. Drug pressure has been identified as a key factor in the emergence of antimalarial drug resistance. Indeed, this pressure is favoured by several factors, including the use of counterfeit forms of antimalarials, inadequate prescription controls, poor adherence to treatment regimens, dosing errors, and the increasing use of other forms of unapproved antimalarials. This resistance has led to the replacement of chloroquine (CQ) by artemisinin-based combination therapies (ACTs) which are likely to become ineffective in the coming years due to the uncontrolled use of Artemisia annua in the sub-Saharan African region for malaria prevention and COVID-19. The use of Artemisia annua for the prevention of malaria and COVID-19 could be an important factor in the emergence of resistance to Artemisinin-based combination therapies.

Indexed as

AntimalarialsArtemisia annuaArtemisininsCOVID-19MalariaMalaria, FalciparumPlasmodiumHumansPlasmodium falciparumAntimalarialsArtemisininsArtemisininCOVID-19MalariaPlasmodium falciparumResistance

Identifiers

PMID34797496
PMCPMC8602884
OpenAlexW3212689604

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.