Evidence map›Paper›PMID 34797390›Full record

ArticleApplied microbiology and biotechnology2021

Detection of synergistic antimicrobial resistance mechanisms in clinical isolates of Pseudomonas aeruginosa from post-operative wound infections.

Asad Bashir Awan, Aixin Yan, Yasra Sarwar, Peter Schierack, Aamir Ali

Abstract read
PubMed Publisher
In one paragraph

Article in Applied microbiology and biotechnology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.4field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Unlocking the potential ofFrontiers in microbiology · 2026
    Article
  2. Review
  3. Review
  4. Biofilm-a Syntrophic Consortia of Microbial Cells: Boon or Bane?Applied biochemistry and biotechnology · 2023
    Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 3 countries.

Asad Bashir AwanNational Institute for Biotechnology and Genetic Engineering College, Pakistan Institute of Engineering and Applied Sciences (NIBGE-C, PIEAS), Faisalabad, Pakistan.ORCID http://orcid.org/0000-0003-4548-1074
Aixin YanSchool of Biological Sciences, University of Hong Kong, Pok Fu Lam, Hong Kong.ORCID http://orcid.org/0000-0003-0310-5492
Yasra SarwarNational Institute for Biotechnology and Genetic Engineering College, Pakistan Institute of Engineering and Applied Sciences (NIBGE-C, PIEAS), Faisalabad, Pakistan.ORCID http://orcid.org/0000-0001-9816-7674
Peter SchierackBrandenburg University of Technology, Campus Senftenberg, Senftenberg, Germany.ORCID http://orcid.org/0000-0002-6445-3506
Aamir AliNational Institute for Biotechnology and Genetic Engineering College, Pakistan Institute of Engineering and Applied Sciences (NIBGE-C, PIEAS), Faisalabad, Pakistan. myaamirali@yahoo.com.ORCID http://orcid.org/0000-0002-8433-4328
National Institute for Biotechnology and Genetic Engineering · PKUniversity of Hong Kong · HKUniversity of Potsdam · DE

Funding

Higher Education Commission, Pakistan (PIN:213-66660-2BM2-192)
6 · The paper itself

Abstract

Infections caused by carbapenem-resistant Pseudomonas aeruginosa are life-threatening due to its synergistic resistance mechanisms resulting in the ineffectiveness of the used antimicrobials. This study aimed to characterize P. aeruginosa isolates for antimicrobial susceptibility, biofilm formation virulence genes, and molecular mechanisms responsible for resistance against various antimicrobials. Out of 700 samples, 91 isolates were confirmed as P. aeruginosa which were further classified into 19 non-multidrug-resistant (non-MDR), 7 multidrug-resistant (MDR), 19 extensively drug-resistant (XDR), and 8 pan drug-resistant (PDR) pulsotypes based on standard Kirby Bauer disc diffusion test and pulse field gel electrophoresis. In M9 minimal media, strong biofilms were formed by the XDR and PDR pulsotypes as compared to the non-MDR pulsotypes. The virulence genes, responsible for the worsening of wounds including LasB, plcH, toxA, and exoU, were detected among all MDR, XDR, and PDR pulsotypes. Carbapenemase activity was phenotypically detected in 45% pulsotypes and the responsible genes were found as bla

Indexed as

Pseudomonas InfectionsWound InfectionAnti-Bacterial Agentsbeta-LactamasesDrug Resistance, BacterialDrug Resistance, Multiple, BacterialHumansMicrobial Sensitivity TestsPseudomonas aeruginosaAnti-Bacterial Agentsbeta-LactamasesAntimicrobial resistanceCarbapenem resistanceMolecular mechanismsPseudomonas aeruginosa

Identifiers

PMID34797390
OpenAlexW3212775169

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.